Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure
Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure
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DOI：
10.1161/01.cir.101.5.498
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发表时间：
2000-02-08
期刊：
影响因子：
37.8
通讯作者：
Kangawa, K
中科院分区：
文献类型：
--
作者：
Nagaya, N;Saloh, T;Kangawa, K
背景-实验研究表明，肾上腺髓质素（AM）引起血管扩张、利尿和正性肌力作用。方法和结果-血液动力学，肾，和激素的反应，静脉输注人AM（0.05 μ g kg（-1）min（-1））进行了检查，在7例CHF患者和7名正常健康受试者（NL）。在NL组，AM显著降低平均动脉压（-16 mm Hg，P
Background-Experimental studies have shown that adrenomedullin (AM) causes vasodilatation, diuresis, and a positive inotropic effect. In humans, however, whether infusion of AM has beneficial effects in congestive heart failure (CHF) remains unknown.Methods and Results- Hemodynamic, renal, and hormonal responses to intravenous infusion of human AM (0.05 mu g kg(-1) min(-1)) were examined in 7 patients with CHF and 7 normal healthy subjects (NL). In NL group, AM significantly decreased mean arterial pressure (-16 mm Hg, P