24-Hour IOP Telemetry in the Nonhuman Primate: Implant System Performance and Initial Characterization of IOP at Multiple Timescales
24-Hour IOP Telemetry in the Nonhuman Primate: Implant System Performance and Initial Characterization of IOP at Multiple Timescales
复制标题
DOI：
10.1167/iovs.11-7955
复制
发表时间：
2011-09-01
影响因子：
4.4
通讯作者：
Sallee, Verney
中科院分区：
文献类型：
--
作者：
Downs, J. Crawford;Burgoyne, Claude F.;Sallee, Verney
目的. IOP是青光眼发生和发展的最常见的独立危险因素，但对IOP动力学知之甚少。在三种非人灵长类动物中使用连续IOP遥测来表征多个时间尺度上多个24小时时段的IOP动态。现有的可植入遥测压力传感器系统适用于监测前房IOP。该系统每秒可记录500次IOP、ECG和体温测量，并能真实的补偿气压。对连续IOP信号进行数字滤波，以消除噪声和丢失，并分别使用时间窗平均值报告3只动物的19、18和4个24小时周期。这些数据被分析为每只动物的昼夜节律模式。多个24小时时段的10分钟时间窗平均值显示，白天IOP在7至14 mm Hg之间波动，并且这些变化频繁且快速发生。三只动物的多个24小时时段的IOP的两小时时间窗平均值显示出弱的昼夜趋势，但IOP在动物体内的日间不可重复。通过使用新的完全植入式IOP遥测系统成功连续测量了测量的IOP。在不受限制的非人灵长类动物中，IOP每天和每小时的波动高达10 mm Hg，这表明快照IOP测量可能不足以捕获IOP的真实动态特征。IOP的分布、幅度和模式在动物体内无法从一天到另一天重现，但当IOP数据在动物体内的多个24小时周期内平均时，夜间IOP往往略高。（Invest Ophthalmol维斯科学。2011;52：7365-7375）DOI：10.1167/iovs.11-7955
PURPOSE. IOP is the most common independent risk factor for development and progression of glaucoma, but very little is known about IOP dynamics. Continuous IOP telemetry was used in three nonhuman primates to characterize IOP dynamics at multiple time scales for multiple 24-hour periods.METHODS. An existing implantable telemetric pressure transducer system was adapted to monitoring anterior chamber IOP. The system records 500 IOP, ECG, and body temperature measurements per second and compensates for barometric pressure in real time. The continuous IOP signal was digitally filtered for noise and dropout and reported using time-window averaging for 19, 18, and 4 24-hour periods in three animals, respectively. Those data were analyzed for a nycthemeral pattern within each animal.RESULTS. Ten-minute time-window averaging for multiple 24hour periods showed that IOP fluctuated from 7 to 14 mm Hg during the day, and those changes occurred frequently and quickly. Two-hour time-window averages of IOP for multiple 24-hour periods in three animals showed a weak nycthemeral trend, but IOP was not repeatable from day-to-day within animals.CONCLUSIONS. The measured IOP was successfully measured continuously by using a new, fully implantable IOP telemetry system. IOP fluctuates as much as 10 mm Hg from day to day and hour to hour in unrestrained nonhuman primates, which indicates that snapshot IOP measurements may be inadequate to capture the true dynamic character of IOP. The distributions, magnitudes, and patterns of IOP are not reproducible from day to day within animals, but IOP tends to be slightly higher at night when IOP data are averaged across multiple 24-hour periods within animals. (Invest Ophthalmol Vis Sci. 2011;52:7365-7375) DOI:10.1167/iovs.11-7955