Sex differences in neural activation following different routes of oxytocin administration in awake adult rats.
Sex differences in neural activation following different routes of oxytocin administration in awake adult rats.
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DOI：
10.1016/j.psyneuen.2017.04.003
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发表时间：
2017-07
影响因子：
3.7
通讯作者：
Veenema AH
中科院分区：
文献类型：
--
作者：
Dumais KM;Kulkarni PP;Ferris CF;Veenema AH
神经肽催产素(OT)以性别特异性的方式调节不同物种的社会行为。OT在缓解性别偏向神经精神障碍的社会缺陷方面有很好的效果。然而，人们对催产素对大脑功能的潜在性二型性影响知之甚少。以大鼠为模型生物，我们确定了催产素的中枢或外周给药是否会导致大脑激活的性别差异。用功能磁共振成像检测清醒大鼠脑室注射(icv；1μg/5μ，L)或腹腔注射(ip；0.1 mg/kg)OT后20min内脑组织血氧水平依赖性(BOLD)信号强度的变化。在所分析的172个脑区中，脑室注射催产素引起的BOLD激活中有26个存在性别差异，其中20个区域在男性(最显著的是伏隔核和岛叶皮质)中表现出更大的激活，6个区域在女性中表现出更大的激活(包括杏仁外侧核和中央杏仁核)。IP OT在BOLD激活中也引起了性别差异，男性的激活量更大，但与ICV OT相比，这种激活在不同的和更少的(10)个脑区被发现。综上所述，外源性催产素对雄性和雌性大鼠神经活动的调节不同，性别差异的模式和大小取决于给药途径，而不是方向。这些发现强调了在基础和临床研究中包括性别的必要性，以充分了解OT对大脑功能的作用。
The neuropeptide oxytocin (OT) regulates social behavior in sex-specific ways across species. OT has promising effects on alleviating social deficits in sex-biased neuropsychiatric disorders. However little is known about potential sexually dimorphic effects of OT on brain function. Using the rat as a model organism, we determined whether OT administered centrally or peripherally induces sex differences in brain activation. Functional magnetic resonance imaging was used to examine blood oxygen level-dependent (BOLD) signal intensity changes in the brains of awake rats during the 20 min following intracerebroventricular (ICV; 1μg/5μl) or intraperitoneal (IP; 0.1mg/kg) OT administration as compared to baseline. ICV OT induced sex differences in BOLD activation in 26 out of 172 brain regions analyzed, with 20 regions showing a greater volume of activation in males (most notably the nucleus accumbens and insular cortex), and 6 regions showing a greater volume of activation in females (including the lateral and central amygdala). IP OT also elicited sex differences in BOLD activation with a greater volume of activation in males, but this activation was found in different and fewer (10) brain regions compared to ICV OT. In conclusion, exogenous OT modulates neural activation differently in male versus female rats with the pattern and magnitude, but not the direction, of sex differences depending on the route of administration. These findings highlight the need to include both sexes in basic and clinical studies to fully understand the role of OT on brain function.