Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hermatopoiesis
Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hermatopoiesis
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DOI：
10.1002/jcb.10271
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Friedman, AD
中科院分区：
文献类型：
--
作者：
Friedman, AD
未成熟的造血前体细胞在分化时增殖，而终末分化与细胞周期停滞有关。干细胞谱系定型和随后的成熟主要受转录因子的调控。Runx 1和c-Myb在早期造血细胞中起作用，刺激增殖和分化，而C/EBPalpha和其他C/EBP家族成员可能阻止从G1到S的进展并诱导终末成熟。通过转录因子将分化与增殖或生长停滞偶联可能是多个发育系统中的重要调控机制。(C)2002 Wiley-Liss，Inc.
Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPalpha, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is likely an important regulatory mechanism in multiple developmental systems. (C) 2002 Wiley-Liss, Inc.