Epiretinal membrane formation after vitrectomy.
Epiretinal membrane formation after vitrectomy.
复制标题
玻璃体切除术后视网膜前膜形成。
DOI：
10.1016/0002-9394(82)90472-x
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发表时间：
1982
影响因子：
4.2
通讯作者：
McDermott,MA
中科院分区：
文献类型：
--
作者：
Stern,WH;Fisher,SK;Anderson,DH;O'Donnell,JJ;Erickson,PA;Lewis,GP;Guerin,CJ;Borgula,GA;McDermott,MA
我们的兔眼晶状体切除术和玻璃体切除术后视网膜前膜形成的实验模型提供了一种研究药物和手术方法的方法，以抑制视网膜前细胞增殖和收缩的眼睛经历了vitrect.We注射400，000组织培养的视网膜色素上皮细胞到视网膜表面的兔眼晶状体切除术，玻璃体切除术，和液气交换。一周后，100%的注射眼出现了髓射线的漏斗状脱离，组织学上，注射后6小时细胞形成视网膜前膜，24 ~ 48小时后引起内层视网膜的大面积脱落。氚化胸苷标记的视网膜前细胞的百分比在注射后24小时急剧增加，然后下降。细胞膜桥接视神经，然后生长和收缩的视网膜前细胞上的分离的内界膜，负责封闭漏斗状外观的髓线。
Our experimental model of epiretinal membrane formation in the rabbit eye after lensectomy and vitrectomy provides a way of studying pharmacologic and surgical approaches to inhibiting epiretinal cellular proliferation and contraction in the eye that has undergone vitrectomy.We injected 400,000 tissue-cultured retinal pigment epithelial cells onto the retinal surface of rabbit eyes that had undergone lensectomy, vitrectomy, and fluid-gas exchange. By one week, a funnel-shaped detachment of the medullary rays had occurred in 100% of the injected eyes.Histologically, the cells formed an epiretinal membrane by six hours after injection and caused major wrinkling of the inner retina after 24 to 48 hours. The percentage of tritiated-thymidine-labeled epiretinal cells increased dramatically 24 hours after injection and then declined. Cellular membranes bridging the optic nerve, followed by growth and contraction of the epiretinal cells on the detached internal limiting membrane, were responsible for the closed funnel appearance of the medullary rays.