Chronic oxidant exposure and epidemic influenza.
Chronic oxidant exposure and epidemic influenza.
复制标题
慢性氧化剂暴露和流行性流感。
DOI：
10.1016/0013-9351(71)90041-7
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发表时间：
1971
影响因子：
8.3
通讯作者：
V. Newill
中科院分区：
文献类型：
--
作者：
M. Pearlman;J. Finklea;C. Shy;J. V. van Bruggen;V. Newill
1968-1969年间，对南加州5个社区的3500名小学生进行了氧化性空气污染对流行的A2/Hong Kong/68流感发病率和持续时间的影响的回顾性研究。在疫情之前和流行期间，社区氧化剂暴露没有差别。学校旷课、问卷调查和血凝抑制效价的信息显示，与污染剂量梯度对应的发病率没有统计学意义上的差异。只有27.2%的儿童保持良好；37.4%的儿童报告了没有发烧的非特异性疾病：13.9%的儿童有发烧的疾病，而不是临床上典型的流感；21.5%的儿童有发烧的临床流感。总体而言，24.6%的患者恢复期血凝抑制效价诊断升高，≥为1：32。女性报告的患病人数更多，但这种过量的情况尚未得到血清学证实。二年级学生报告的疾病较多，但III滴度较低，可能是因为他们缺乏年龄较大的儿童的免疫经验。在10.3%的人群中观察到了亚临床流感的一个指标，即血凝抑制效价≥1：32。根据临床疾病的定义，临床与亚临床的比率从2.3到6.3不等。流感与平均3.3天的缺课和平均6.3-7.4天的限制活动期有关。
The effect of oxidant air pollution upon epidemic A2/Hong Kong/68 influenza incidence and duration was studied retrospectively during 1968–1969 among 3500 elementary school children from five Southern California communities selected to represent a chronic exposure gradient. No difference in community oxidant exposure was present just prior to and during the epidemic. Information from school absenteeism, questionnaires, and hemagglutination-inhibition titers revealed no statistically significant morbidity differences corresponding to the pollution dose gradient. Only 27.2% of the children remained well; 37.4% reported nonspecific illness without fever: 13.9% had a febrile illness not clinically typical of influenza; and 21.5% had febrile clinical influenza. Overall, 24.6% had diagnostically elevated convalescent hemagglutination-inhibition titers, ≥ 1:32. Females reported more illness but this excess was not serologically confirmed. Second graders reported more illness but exhibited lower III titers, probably because they lacked the immunologic experience of older children. An index of subclinical influenza, a hemagglutination inhibition titer ≥ 1:32 without illness, was observed in 10.3% of the population. The clinical to subclinical ratio ranged from 2.3 to 6.3 depending on the definition of clinical illness. Influenza was associated with school absences averaging 3.3 days, and periods of restricted activity averaging 6.3–7.4 days.