Azaphilones: a class of fungal metabolites with diverse biological activities
Azaphilones: a class of fungal metabolites with diverse biological activities
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DOI：
10.1007/s11101-010-9171-3
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发表时间：
2010-06-01
影响因子：
7.7
通讯作者：
Ayoub, Nahla
中科院分区：
文献类型：
--
作者：
Osmanova, Natalia;Schultze, Wulf;Ayoub, Nahla
本文综述了近年来从不同真菌中分离得到的氮杂环酮类化合物的化学结构和生物活性。在13科23属真菌中发现了170多种不同的氮杂环酮类化合物：这些氮杂环酮类化合物可分为10个不同的结构群。已经描述了许多氮杂环酮结构，特别是来自木霉科和木犀草科的成员。氮杂环酮类化合物具有广泛的生物活性，如抗菌、抗真菌、抗病毒、抗氧化、细胞毒性、杀线虫和抗炎活性。这些效应中的许多可以通过氮杂环酮与氨基的反应来解释，例如氨基酸、蛋白质和核酸中的氨基，从而形成乙烯基伽马-吡啶酮。
This review presents an overview of azaphilones isolated from different species of fungi, detailing their chemical structures and biological activities as covered in the recent literature. Over 170 different azaphilone compounds occur in fungi belonging to 23 genera from 13 families: these azaphilones can be classified into ten different structural groups. Numerous azaphilone structures have been described, particularly from members of the Trichocomaceae and Xylariaceae families. Azaphilones exhibit a wide range of interesting biological activities, such as antimicrobial, antifungal, antiviral, antioxidant, cytotoxic, nematicidal and anti-inflammatory activities. Many of these effects may be explained by the reactions of azaphilones with amino groups, such as those found in amino acids, proteins and nucleic acids, resulting in the formation of vinylogous gamma-pyridones.