Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study
Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study
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DOI：
10.3233/rnn-2009-0483
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Bergado, Jorge A.
中科院分区：
文献类型：
--
作者：
Suarez-Monteagudo, Carlos;Hernandez-Ramirez, Porfirio;Bergado, Jorge A.
目的：对5例脑卒中后遗症患者的病灶周围移植骨髓干细胞（BMSC），评价移植手术的安全性和对移植细胞的耐受性。方法：从同一患者的骨髓样本中获得细胞，并以立体定向方式植入目标，使用图像组合和术中多单位活动记录来确定。这些细胞沿着病灶周围的束被植入几个点。结果：在一年的随访期间，没有观察到手术或移植引起的重要不良事件，也没有通过术前和术后的综合检查和功能测量检测到。相比之下，在患者的神经系统状况方面观察到一些改善，但研究中的少数患者不允许任何结论性陈述。结论：我们的研究结果表明，使用本文描述的方法，BMSC可以安全地移植到患者的大脑中，具有良好的耐受性和无并发症。
Purpose: Bone marrow stem cells (BMSC) were transplanted into the perilesional area in five patients bearing sequels of stroke, to evaluate the safety of the procedure and tolerance to the transplanted cells.Methods: Cells were obtained from bone marrow samples taken from the same patient and stereotactically implanted into the targets, determined using a combination of images, and trans-operative recording of multiunit activity. The cells were implanted in several points along tracts in the perilesional region.Results: No important adverse events derived from surgery or transplant were observed during the one year follow-up period, or detected using a combination of tests and functional measurements applied pre- and post-surgically. In contrast, some improvements were observed regarding the neurological condition of the patients, but the small number of patients in the study does not allow any conclusive statement.Conclusions: Our results demonstrate that BMSC can be safely transplanted into the brain of patients, with excellent tolerance and without complications, using the methods described here.