Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease.
Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease.
复制标题
尿失禁相关对帕金森病患者功能连接回路的影响。
DOI：
10.1002/nau.25258
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发表时间：
2023
影响因子：
2
通讯作者：
Vaughan,CamilleP
中科院分区：
文献类型：
--
作者：
Denmon,Chanse;Wakeman,DanielG;Vernon,Mark;McGregor,Keith;Krishnamurthy,Venkatagiri;Krishnamurthy,Lisa;Stevens,Jennifer;Vaughan,CamilleP
简介尿失禁 (UI) 是帕金森病 (PD) 的常见破坏性症状。本研究旨在确定患有 UI 的 PD 患者 (UI-PD) 与没有 UI 的 PD 患者 (nonUI-PD) 相比与 UI 相关的神经相关性，期望证明纹状体和边缘系统区域之间的功能连接 (FC) 增加，而执行区域的 FC 减少。 方法 rsfMRI 和 T1w 数据 (n= 119) 取自帕金森病进展标志物倡议 (PPMI)。静息态 FC 分析评估了前扣带回、楔前叶和壳核种子区域的时间协方差。结果相对于患有 PD 但没有 UI 的个体（n= 87、18女性）。相对于非 UI-PD 组，UI-PD 组在前扣带回种子和直角回之间表现出更大的负 FC（p< 0.01）。 结论 与 PD 和非 UI 患者相比，患有 PD 和 UI 的个体在可能受 PD 影响的神经回路内（例如壳核和尾状核之间，以及与脑膀胱控制相关的神经回路内）显示出更强的 FC。基于本研究结果的临床应用可以为 UI-PD 患者的治疗策略提供更大的辨别力。
IntroductionUrinary incontinence (UI) is a common and disruptive symptom of Parkinson's disease (PD). This study aimed to identify neural correlates associated with UI among PD patients with UI (UI‐PD) compared to those PD patients without UI (nonUI‐PD) with the expectation of demonstrating increased functional connectivity (FC) between areas in the striatum and limbic system and decreased FC in executive areas.MethodsrsfMRI and T1w data (n= 119) were retrieved from the Parkinson's Progression Markers Initiative (PPMI). Resting‐state FC analyses assessed temporal covariance with anterior cingulate gyrus, precuneus, and putamen seed regions.ResultsThe UI‐PD group (n= 32, 16 females) showed significantly greater positive FC between the bilateral putamen seed and the right caudate and right thalamus (p< 0.01), relative to individuals with PD but who did not have UI (n= 87, 18 females). The UI‐PD group showed greater negative FC between the anterior cingulate seed and right angular gyrus (p< 0.01) relative to nonUI‐PD.ConclusionIndividuals with PD and UI display stronger FC within neural circuits likely affected by PD such as between the putamen and caudate, as well as within those associated with brain bladder control, compared to persons with PD and without UI. Clinical application based on this study's results can provide greater discernment of treatment strategies for UI‐PD patients.