Human papillomavirus infections among couples in new sexual relationships.
Human papillomavirus infections among couples in new sexual relationships.
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DOI：
10.1097/ede.0b013e3181c1e70b
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发表时间：
2010-01
期刊：
影响因子：
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通讯作者：
Franco EL
中科院分区：
文献类型：
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作者：
Burchell AN;Tellier PP;Hanley J;Coutlée F;Franco EL
目前还没有研究对夫妻在性关系早期感染人乳头瘤病毒（HPV）的情况进行调查，而这一阶段是最有可能传播的。我们的目标是描述HPV感染的分布在最近形成的夫妇，使用伙伴关系作为分析单位。在蒙特利尔就读大学或大专的18-24岁的女性与她们的新男性伴侣一起参加了一项纵向研究。对自己收集的阴道拭子和临床收集的阴茎和阴囊拭子进行了36种HPV基因型检测。参与者在电脑调查问卷中自我报告性行为。我们使用入组时获得的数据分析了263对夫妇的生殖器HPV感染模式。夫妻进行阴道性交的平均时间为3.9个月。64%（169/263）的夫妇检出HPV。在41%（109/263）中，伴侣双方都携带相同的HPV类型——如果伴侣的HPV状况不相关，这一数字几乎是预期的4倍。在169对夫妇中，有583人感染了特定类型的HPV，其中至少有一方感染。其中，42%的伴侣双方都是同一类型（95%置信区间= 36%-47%）。这一比例在持续不到2个月的女性中从25%上升到5到6个月的68%。虽然HPV很常见，但在开始性关系的人中检测到相同类型的HPV是罕见的，因为这是特定类型的流行率。我们发现的高度一致性表明传播的可能性很大。
No studies have examined human papillomavirus (HPV) infections among couples early in their sexual relationships when transmission is most likely. Our objective was to describe the distribution of HPV infections among recently formed couples, using the partnership as the unit of analysis. Women aged 18–24 years attending a university or junior college in Montreal enrolled in a longitudinal study with their new male partners. Self-collected vaginal swabs and clinician-collected swabs from the penis and scrotum were tested for 36 HPV genotypes. Participants self-reported sexual behavior in computerized questionnaires. We analyzed patterns of genital HPV infection in 263 couples using data obtained at enrollment. Couples had engaged in vaginal sex for a median of 3.9 months. HPV was detected in 64% (169/263) of couples. In 41% (109/263), both partners harbored the same HPV type—nearly 4 times more than expected if HPV status of partners were uncorrelated. There were 583 type-specific HPV infections among 169 couples for whom at least one partner was infected. Of these, 42% were of the same type for both partners (95% confidence interval = 36%–47%). This rose from 25% among those engaging in vaginal sex for less than 2 months to 68% among those at 5 to 6 months. Although HPV is common, detection of the same type in persons initiating a sex relationship would be rare given type-specific prevalence rates. The high degree of concordance we found suggests a high probability of transmission.