Human metapneumovirus infection in hospital referred South African children
Human metapneumovirus infection in hospital referred South African children
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DOI：
10.1002/jmv.20116
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发表时间：
2004-07-01
影响因子：
12.7
通讯作者：
Osterhaus, DME
中科院分区：
文献类型：
--
作者：
Ijpma, FFA;Beekhuis, D;Osterhaus, DME
人偏肺病毒（hMPV）首次在荷兰儿童急性呼吸道症状中被发现。通过RT-PCR、病毒培养和酶联免疫吸附试验，在一个冬季对南非因上呼吸道或下呼吸道感染而转诊到医院的儿童进行了hMPV和其他呼吸道病毒的流行病学、临床表现和血清阳性率的前瞻性分析。在137例儿童鼻咽分泌物中，RT-PCR检测到8例（5.8%）儿童（2-43月龄）的hMPV是唯一的病毒病原体，呼吸道合胞病毒（RSV） 21例（15%），甲型流感病毒18例（13%），乙型流感病毒20例（15%）。7名儿童被诊断为肺炎，1名hmpv感染儿童被诊断为上呼吸道感染。一名感染hmpv的儿童被送进重症监护室，需要机械通气，一名儿童感染了人类免疫缺陷病毒（HIV）。hMPV、RSV和流感病毒感染组在临床体征、症状和胸片表现方面没有统计学上的显著差异。24 ~ 36月龄儿童hMPV特异性IgG抗体血清阳性率为92%，本组血清阴性儿童年龄最大为7岁6月龄。总之，hMPV是南非儿童上呼吸道和下呼吸道发病的原因之一。(C) 2004 Wiley-Liss, Inc。
Human metapneumovirus (hMPV) was first described in Dutch children with acute respiratory symptoms. A prospective analysis of the epidemiology, clinical manifestation, and seroprevalence of hMPV and other respiratory viruses in South African children referred to hospital for upper or lower respiratory tract infection were carried out during a single winter season, by using RT-PCR, viral culture, and enzyme-linked immunosorbent assays. In nasopharyngeal aspirates from 137 children, hMPV was detected by RT-PCR in 8 (5.8%) children (2-43 months of age) as a sole viral pathogen, respiratory syncytial virus (RSV) in 21 (15%), influenza A virus in 18 (13%) and influenza B virus in 20 (15%). Pneumonia was diagnosed in seven children and upper respiratory tract infection in one of the hMPV-infected children. One hMPV-infected child was admitted to the intensive care unit in need of mechanical ventilation and one child was infected with human immunodeficiency virus (HIV). No statistically significant differences were found between hMPV, RSV, and influenza virus infected groups with regard to clinical signs and symptoms and chest radiograph findings. The seropositive rate of hMPV specific IgG antibodies was 92% in children aged 24-36 months, the oldest seronegative child in our study was 7 years and 6 months of age. In conclusion, hMPV contributes to upper and lower respiratory tract morbidity in South African children. (C) 2004 Wiley-Liss, Inc.