Aging and synaptic plasticity: A review.
Aging and synaptic plasticity: A review.
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DOI：
10.1155/np.2002.217
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发表时间：
2002-01-01
影响因子：
3.1
通讯作者：
Almaguer, William
中科院分区：
文献类型：
--
作者：
Bergado, Jorge A.;Almaguer, William
衰老会影响所有的系统，但大脑似乎特别容易受到负面的、与年龄相关的因素的影响。记忆功能的逐渐丧失是大脑老化最早和最普遍的后果之一。该等减值的原因仍不清楚。长时程增强（LTP）是神经可塑性的一种形式，被认为与记忆有关。LTP受年龄的影响，这种改变可能与记忆功能障碍有因果关系。在本文中，我们审查的证据支持存在的因果关系之间的联系，认知和LTP的损害，以及可能的机制。新的研究结果表明，可能涉及的LTP的情感影响的不足加强。
Aging affects all systems, but the brain seems to be particularly vulnerable to the action of negative, age-dependent factors. A gradual loss of memory functions is one of the earliest and most widespread consequences of brain aging. The causes for such impairment are still unclear. Long-term potentiation (LTP) is one form of neural plasticity, which has been proposed as the cellular correlate for memory. LTP is affected by aging, and such alteration might be causally related to memory dysfunction. In the present paper, we review the evidence sustaining the existence of a causal link between cognitive and LTP impairments, as well as the possible mechanisms involved. New results indicate a possible involvement of a deficient reinforcement of LTP by affective influences.