Symbolic representations of action in the human cerebellum
Symbolic representations of action in the human cerebellum
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DOI：
10.1016/j.neuroimage.2008.07.010
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发表时间：
2008-11-01
期刊：
影响因子：
5.7
通讯作者：
Ramnani, N.
中科院分区：
文献类型：
--
作者：
Balsters, J. H.;Ramnani, N.
连接到新皮层运动系统的小脑皮质区域处理对动作的感觉指导重要的信息。越来越多的证据也支持这样一种观点，即与前额皮质相连的小脑皮质区域在认知领域处理信息的方式相似。在这里，我们验证了人类小脑的前额叶投射区处理嵌入在感觉线索中的信息的抽象内容的假设。具体来说，我们使用与事件相关的功能磁共振成像来确定象征性视觉指令是否激活了小脑的前额叶投射区。根据连接解剖学，我们预测这种活动将在同一小叶的HVIIA小叶和邻近的垂直区域中发现。我们的实验设计使我们能够调查特定于动作指令的活动，这些指令要么是纯粹的象征性的，要么是直接指定的动作。这种活动是独立于行动的。与非符号控制信号相比，符号信号在特定时间锁定的活动激活了小脑皮质小叶HVIIA（小腿I和小腿II）。我们的研究结果支持小脑皮层前额叶突出区域处理纯粹抽象性质的信息的观点。(c) 2008爱思唯尔公司版权所有。
Cerebellar cortical areas connected to the neocortical motor system process information important for the sensory guidance of action. Converging evidence also supports the view that cerebellar cortical areas connected with the prefrontal cortex process information similarly in the cognitive domain. Here, we test the hypothesis that the prefrontal-projecting zones in the human cerebellum process the abstract content of information embedded within sensory cues. Specifically, we use event-related fMRI to determine whether symbolic visual instructions activate the prefrontal-projecting zones of the cerebellum. On the basis of connectional anatomy, we predicted that such activity would be found in lobule HVIIA and adjacent vermal territories in the same lobule. Our experimental design enabled us to investigate activity time-locked specifically to instructions for action that were either purely symbolic, or specified actions directly. Such activity was independent of action. Activity specifically time-locked to symbolic cues (compared with non-symbolic control cues) activated cerebellar cortical lobule HVIIA (Crus I and Crus II). Our results Provide support for the view that prefrontal-projecting areas of the cerebellar cortex process information that is of a purely abstract nature. (c) 2008 Elsevier Inc. All rights reserved.