Lack of association between apelin, insulin resistance, cardiovascular risk factors, and obesity in children: a longitudinal analysis
Lack of association between apelin, insulin resistance, cardiovascular risk factors, and obesity in children: a longitudinal analysis
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DOI：
10.1016/j.metabol.2011.02.005
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发表时间：
2011-09-01
影响因子：
9.8
通讯作者：
Roth, Christian L.
中科院分区：
文献类型：
--
作者：
Reinehr, Thomas;Woelfle, Joachim;Roth, Christian L.
Apelin是一种新型的有益脂肪因子，与胰岛素抵抗、心血管危险因素和肥胖相关。然而，在人类中的发现是有争议的;在儿童期的纵向分析仍然缺失。我们比较了年龄、性别和青春期相同的80名肥胖儿童和40名消瘦儿童的apelin水平。此外，我们分析了80名肥胖儿童在参与1年生活方式干预前后apelin水平与体重状态（作为体重指数[SDS-BMI]的标准差）、体脂、胰岛素抵抗（稳态模型评估[HOMA]）、瘦素和肥胖相关的心血管危险因素（腰围、血压、血脂和脂联素）之间的关系。肥胖儿童（1.50 +/- 0.47 ng/mL，平均值+/- SD）和瘦儿童（1.67 +/- 0.49 ng/mL）之间的爱帕琳素水平无显著差异（P = 0.061）。Apelin浓度与年龄、青春期阶段、SDS-BMI、体脂、瘦素或任何心血管危险因素均无显著相关性。在纵向分析中，未发现apelin的变化与SDS-BMI、体脂、瘦素、HOMA或任何心血管危险因素的变化之间存在显著相关性。在39名SDS-BMI降低的肥胖儿童中，脂联素、HOMA、血压、腰围和甘油三酯显著改善，而这些儿童中瘦素显著降低，apelin没有显著变化。41例SDS-BMI增高的患儿，随访1年，无明显变化。这是第一项研究表明，肥胖儿童的体重减轻与apelin浓度的变化无关。我们的数据并不支持在儿童时期爱帕琳蛋白与瘦素、HOMA、心血管危险因素或体重状况之间存在显著关系。(C)2011 Elsevier Inc. All rights reserved.
Apelin has been proposed as a novel beneficial adipokine that is related to insulin resistance, cardiovascular risk factors, and obesity. However, findings in humans are controversial; and longitudinal analyses in childhood are still missing. We compared apelin levels between 80 obese and 40 lean children of the same age, sex, and pubertal stage. In addition, we analyzed the relationships between apelin levels and weight status (as standard deviation of body mass index [SDS-BMI]), body fat, insulin resistance (homeostasis model assessment [HOMA]), leptin, and cardiovascular risk factors associated with obesity (waist circumference, blood pressure, lipids, and adiponectin) in 80 obese children before and after participating in a 1-year lifestyle intervention. Apelin levels did not differ significantly (P = .061) between obese (1.50 +/- 0.47 ng/mL, mean +/- SD) and lean children (1.67 +/- 0.49 ng/mL). Apelin concentrations were not significantly related to age, pubertal stage, SDS-BMI, body fat, leptin, or any cardiovascular risk factor. In longitudinal analyses, no significant correlations were found between changes of apelin and changes of SDS-BMI, body fat, leptin, HOMA, or any cardiovascular risk factor. Adiponectin, HOMA, blood pressure, waist circumference, and triglycerides improved significantly in 39 obese children with SDS-BMI reduction, whereas leptin decreased significantly and apelin did not change significantly in these children. In 41 children with increase of SDS-BMI, no significant changes were observed in 1-year follow-up period. This is the first study demonstrating that weight loss in obese children was not associated with a change of apelin concentrations. Our data do not support a significant relationship in childhood between apelin on one hand and leptin, HOMA, cardiovascular risk factors, or weight status on the other. (C) 2011 Elsevier Inc. All rights reserved.