Deontological and Altruistic Guilt: Evidence for Distinct Neurobiological Substrates
Deontological and Altruistic Guilt: Evidence for Distinct Neurobiological Substrates
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DOI：
10.1002/hbm.21009
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发表时间：
2011-02-01
影响因子：
4.8
通讯作者：
Bozzali, Marco
中科院分区：
文献类型：
--
作者：
Basile, Barbara;Mancini, Francesco;Bozzali, Marco
内疚感是一种复杂的心理状态，它是人类在私人生活和社会生活中的几种行为的基础。从心理学和进化论的角度来看，内疚是一种情感和认知功能，其特征是亲社会情绪，需要特定的道德信仰，这可能主要是由内在价值观（义务内疚）或更多的人际关系（利他内疚）驱动。本研究的目的是调查是否有一个不同的神经生物学基板，这两个表达的内疚在健康人。我们首先进行了两项行为研究，招募了72名健康志愿者的样本，以验证一组刺激选择性地唤起义务论和利他主义内疚，或基本控制情绪（即，愤怒和悲伤）。在一个新的样本中，22名健康志愿者在事件相关功能磁共振成像（fMRI）范式中再现了类似的刺激，以研究相同情绪的神经相关性。我们发现，与愤怒和悲伤相比，内疚情绪会激活特定的大脑区域（即，扣带回和内侧额叶皮层），不同的神经元网络参与每一种特定的内疚，与神经元选择性地响应义务内疚刺激。这项研究提供了证据，证明存在不同的神经回路参与不同的内疚感。这种复杂的情绪可以解释正常的个人态度和异常的社会行为。此外，对特定内疚感的异常处理可能会导致一些精神病理学表现，如强迫症和抑郁症。《脑地图》32：229-239，2011年。(C)2010 Wiley-Liss，Inc.
The feeling of guilt is a complex mental state underlying several human behaviors in both private and social life. From a psychological and evolutionary viewpoint, guilt is an emotional and cognitive function, characterized by prosocial sentiments, entailing specific moral believes, which can be predominantly driven by inner values (deontological guilt) or by more interpersonal situations (altruistic guilt). The aim of this study was to investigate whether there is a distinct neurobiological substrate for these two expressions of guilt in healthy individuals. We first run two behavioral studies, recruiting a sample of 72 healthy volunteers, to validate a set of stimuli selectively evoking deontological and altruistic guilt, or basic control emotions (i.e., anger and sadness). Similar stimuli were reproduced in a event-related functional magnetic resonance imaging (fMRI) paradigm, to investigate the neural correlates of the same emotions, in a new sample of 22 healthy volunteers. We show that guilty emotions, compared to anger and sadness, activate specific brain areas (i.e., cingulate gyrus and medial frontal cortex) and that different neuronal networks are involved in each specific kind of guilt, with the insula selectively responding to deontological guilt stimuli. This study provides evidence for the existence of distinct neural circuits involved in different guilty feelings. This complex emotion might account for normal individual attitudes and deviant social behaviors. Moreover, an abnormal processing of specific guilt feelings might account for some psychopathological manifestation, such as obsessive-compulsive disorder and depression. Hum Brain Mapp 32: 229-239, 2011. (C) 2010 Wiley-Liss, Inc.