Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune
Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune
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DOI：
10.1016/j.carbpol.2010.10.046
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发表时间：
2011-02-01
影响因子：
11.2
通讯作者：
Huang, Zebo
中科院分区：
文献类型：
--
作者：
Li, Haifeng;Xu, Juan;Huang, Zebo
可食用地木耳菌落的主要支持基质是多糖，它在保护蓝藻自身免受极端干燥和高辐射的影响方面起着重要作用。为了从多糖的固有性质探索生物医学潜力，我们研究了聚合物的抗氧化和保湿能力。我们在这里报告，多糖是能够清除超氧阴离子和羟基自由基在体外。以秀丽隐杆线虫为模型动物。我们进一步表明，多糖可以提高抗氧化酶活性，降低脂质过氧化水平，并减少百草枯诱导的氧化损伤。我们还发现，多糖具有较强的体外吸湿和保湿能力相比，壳聚糖和尿素，并能够提高小鼠角质层在干燥条件下的保水性。总之，这些数据表明，在体外以及在体内的抗氧化活性和强大的保湿能力的多糖从N。公社。(C)2010爱思唯尔有限公司保留所有权利。
The main supporting matrix of the edible Nostoc commune colony is polysaccharide, which plays important roles in protecting the cyanobacterium itself from extreme desiccation and high radiation. To explore biomedical potential from the inherent nature of the polysaccharide, we investigated antioxidant and moisture-retention capacities of the polymer. We report here that the polysaccharide is capable of scavenging both superoxide anion and hydroxyl radicals in vitro. Using the model animal Caenorhabditis elegans. we further show that the polysaccharide can increase antioxidant enzyme activity, decrease lipid peroxidation level, and reduce paraquat-induced oxidative damage. We also reveal that the polysaccharide has strong in vitro moisture-absorption and -retention capacities as compared to chitosan and urea, and is able to improve water retention in mouse stratum corneum under dry conditions. Together, these data demonstrate the potent in vitro as well as in vivo antioxidant activities and strong moisture-retention capacities of the polysaccharide from N. commune. (C) 2010 Elsevier Ltd. All rights reserved.