Construction and First Tests of an in-beam PET Demonstrator Dedicated to the Ballistic Control of Hadrontherapy Treatments With 65 MeV Protons
Construction and First Tests of an in-beam PET Demonstrator Dedicated to the Ballistic Control of Hadrontherapy Treatments With 65 MeV Protons
复制标题
专用于 65 MeV 质子强子治疗弹道控制的束内 PET 演示器的构建和首次测试
DOI：
10.1109/trpms.2017.2780447
复制
发表时间：
2018
影响因子：
4.4
通讯作者：
Gerard Montarou
中科院分区：
文献类型：
--
作者：
S. Binet;A. Bongrand;E. Busato;P. Force;C. Guicheney;C. Insa;D. Lambert;M. Magne;F. Martin;H. Perrin;F. Podlyski;A. Rozes;Gerard Montarou
本文介绍了强子疗法治癌束流弹道控制演示器的结构和首次质子束流试验。这种具有成本效益的演示器称为大面积像素化探测器，是一种用于束内弹道控制的PET类探测器。它的建立是为了测试在真实的时间监测的可行性，在照射过程中，通过测量束流诱导的$\beta^{+}$活动分布的离子范围在病人。实现这一目标需要克服若干挑战。其中之一是抑制光束诱导背景。另一个是快速事件选择和重建技术的定义，使得真实的时间监测是可能的。采用的策略来解决这些问题，并测试与65 MeV的Medicyc质子束的癌症治疗中心在法国尼斯。特别是，一个原始的快速重建技术。介绍了聚甲基丙烯酸甲酯靶在辐照过程中获得的第一批性能。
The construction and first proton beam tests of a demonstrator dedicated to the beam ballistic control in hadrontherapy cancer treatments are described. This cost-effective demonstrator, called large area pixelized detector, is a PET-like detector used for in-beam ballistic control. It was built to test the feasibility of monitoring in real time, during irradiation, the ion range in the patient through the measurement of the beam-induced $\beta^{+}$ activity distribution. Achieving this goal necessitates to overcome several challenges. One of them is the rejection of the beam-induced background. Another one is the definition of fast event selection and reconstruction techniques so that real time monitoring is possible. Strategies employed to tackle these problems are presented and tested with the 65 MeV Medicyc proton beam of the cancer treatment center in Nice, France. In particular, an original fast reconstruction technique is presented. First performances obtained during irradiation of polymethyl methacrylate targets are described.