GENE-THERAPY FOR INFECTIOUS-DISEASES - THE AIDS MODEL
GENE-THERAPY FOR INFECTIOUS-DISEASES - THE AIDS MODEL
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DOI：
10.1016/0168-9525(94)90216-x
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发表时间：
1994-04-01
影响因子：
11.4
通讯作者：
SMITH, C
中科院分区：
文献类型：
--
作者：
GILBOA, E;SMITH, C
体细胞的遗传操作可能在多种感染性疾病中具有治疗价值，特别是在人类免疫缺陷病毒（HIV）感染中。将定制设计的“抗性基因”稳定插入对HIV易感的细胞中可以减少感染个体的病毒负担，并可能延缓特征性的进行性免疫功能障碍。或者，编码病毒抗原的基因的异位表达可能诱导有效的抗病毒免疫应答，并形成新的预防性和治疗性疫苗的基础。虽然实验室研究已经证明该方法在原则上有效，但临床前和临床研究将是必要的，以评估这种基于基因的疗法的治疗益处。
Genetic manipulation of somatic cells may be of therapeutic value in a variety of infectious diseases, particularly in human immunodeficiency virus (HIV) infection. Stable insertion of custom-designed 'resistance genes' into cells susceptible to HIV could reduce the viral burden in infected individuals and potentially retard the characteristic progressive immune dysfunction. Alternatively, ectopic expression of genes that encode viral antigens might induce potent antiviral immune responses and form the basis for novel prophylactic and therapeutic vaccines. While laboratory studies have proved that the approach works in principle, preclinical and clinical studies will be necessary to evaluate the therapeutic benefit of such gene-based therapies.