Resolving a catch-22 in cardiac gene regulation.
Resolving a catch-22 in cardiac gene regulation.
复制标题
解决心脏基因调控中的第 22 条军规。
DOI：
10.1161/circulationaha.112.110767
复制
发表时间：
2012
期刊：
影响因子：
37.8
通讯作者：
Dorn2nd,GeraldW
中科院分区：
文献类型：
--
作者：
Dorn2nd,GeraldW
You have a big heart.” These five words have almost as many implications. Being big hearted can describe a generous and giving nature. In a different context, Secretariat’s heart was unusually large because he carried an X-linked gene1 conferring on him rare physiological attributes that in 1973 propelled him to thoroughbred horse racing’s Triple Crown. When the same declaration occurs between cardiologist and patient, however, the connotation is overwhelmingly negative. Heart enlargement from cardiac hypertrophy or dilated cardiomyopathy is a powerful positive predictor of morbidity and mortality. 2, 3 Accordingly, efforts to more fully understand the molecular underpinnings of structural and functional cardiac remodeling have been a major focus of basic cardiovascular research since genetic reprogramming was first mechanistically linked to cardiac hypertrophy. 4, 5 Over the past 25 years major transcriptional controls for pathological cardiac gene expression have been defined and suggested novel genetic approaches to control or reverse hypertrophy. 6
