Promotion of photomorphogenesis by COP1
Promotion of photomorphogenesis by COP1
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DOI：
10.1007/s11103-004-5919-8
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发表时间：
2004-12-01
影响因子：
5.1
通讯作者：
Casal, JJ
中科院分区：
文献类型：
--
作者：
Boccalandro, HE;Rossi, MC;Casal, JJ
组成型光形态发生蛋白1（COP 1）通过靶向定位于核的转录因子到蛋白酶体介导的降解来抑制黑暗中的光形态发生。在光照下，COP 1迁移到胞质溶胶中，允许光形态发生进行，但残留的核池下调光敏色素A介导的光信号。在这里，我们表明，弱等位基因cop 1表现出反向光形态发生反应。减少而不是增强子叶unfoldingunder红光相比黑暗。相反，在蓝光或远红光下黄化较差的COP 1过表达体在红光下表现出增强的光形态建成。光合色素B与COP 1的表达呈正相关。因此，COP 1水平的遗传操纵差异影响光敏色素A-相比光敏色素B介导的反应。我们推测COP 1可能参与光形态建成负调控因子的降解或转录激活，如在哺乳动物发育中观察到的一些E3连接酶。
CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) represses photomorphogenesis in darkness by targeting nuclear-localized transcription factors to proteasome-mediated degradation. Upon light exposureCOP1 migrates to the cytosol allowing photomorphogenesis to proceed but the residual nuclear pool down-regulates light signaling mediated by phytochrome A. Here we show that weak alleles of cop1 exhibit reverse photomorphogenic responsesi.e. reduced rather than enhanced cotyledon unfoldingunder red light compared to darkness. ConverselyCOP1 overexpressorswhich de-etiolate poorly under blue or far-red lightshowed enhanced photomorphogenesis under red light. The positive relationship between COP1 and photomorphogenic response required phytochrome B. Thusgenetic manipulation of COP1 levels differentially affects phytochrome A- compared to phytochrome B-mediated responses. We hypothesize that COP1 could be involved in degradation of negative regulators of photomorphogenesis or in transcriptional activationas observed for some E3 ligases in mammalian development.