Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial
Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial
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DOI：
10.1002/oby.21396
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发表时间：
2016-04-01
期刊：
影响因子：
6.9
通讯作者：
Hecht, Frederick M.
中科院分区：
文献类型：
--
作者：
Daubenmier, Jennifer;Moran, Patricia J.;Hecht, Frederick M.
ObjectiveTo determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.MethodsIn this study 194名肥胖成年人被随机分配到一个5.5个月的计划，有或没有正念训练和相同的饮食运动指南。对于缺失数据，采用多重插补的意向治疗分析。主要结果是18个月的体重变化。结果估计效果比较正念控制手臂赞成正念手臂在（a）体重减轻12个月，-1.9公斤（95% CI：-4.5，0.8; P=0.17），18个月，-1.7 kg（95% CI：-4.7，1.2; P=0.24），但无统计学显著性;（B）12个月时空腹血糖的变化，-3.1 mg/dl（95% CI：-6.3，0.1; P=0.06），18个月，-4.1 mg/dl（95% CI：-7.3，-0.9; P=0.01）;和（c）12个月时甘油三酯/HDL比值的变化，-0.57（95%CI：-0.95，-0.18; P=0.004），18个月时为-0.36（95%CI：-0.74，0.03; P=0.07）。其他代谢危险因素的估计没有统计学意义，包括腰围，血压，和C-反应蛋白。ConclusionsMindfulness增强饮食锻炼计划并没有表现出显着的减肥效果，但可能会促进长期改善某些方面的代谢健康的肥胖症，需要进一步研究。
ObjectiveTo determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.MethodsIn this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change.ResultsEstimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P=0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P=0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P=0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P=0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P=0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P=0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein.ConclusionsMindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.