Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
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基于黄嘌呤的腺苷受体拮抗剂的设计和评估：潜在的缺氧靶向免疫疗法。
DOI：
10.1016/j.bmc.2013.09.043
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发表时间：
2013
影响因子：
3.5
通讯作者：
Jones,GrahamB
中科院分区：
文献类型：
--
作者：
Thomas,Rhiannon;Lee,Joslynn;Chevalier,Vincent;Sadler,Sara;Selesniemi,Kaisa;Hatfield,Stephen;Sitkovsky,Michail;Ondrechen,MaryJo;Jones,GrahamB
应用分子建模技术设计、合成和优化一系列新的基于黄嘌呤的腺苷A2A受体拮抗剂。将优化的先导化合物转化为 PEG 衍生物，并使用功能性体外生物测定来确认功效。此外，聚乙二醇化版本显示出增强的水溶性，并且对光异构化呈惰性，这是此类现有拮抗剂的已知限制。
Molecular modeling techniques were applied to the design, synthesis and optimization of a new series of xanthine based adenosine A2Areceptor antagonists. The optimized lead compound was converted to a PEG derivative and a functional in vitro bioassay used to confirm efficacy. Additionally, the PEGylated version showed enhanced aqueous solubility and was inert to photoisomerization, a known limitation of existing antagonists of this class.