Biomechanical modulation of endothelial phenotype: implications for health and disease.
Biomechanical modulation of endothelial phenotype: implications for health and disease.
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内皮表型的生物力学调节：对健康和疾病的影响。
DOI：
10.1007/3-540-36028-x_3
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发表时间：
2006
影响因子：
--
通讯作者：
GimbroneJr,MA
中科院分区：
文献类型：
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作者：
García-Cardeña,G;GimbroneJr,MA
血管内皮的功能表型可塑性依赖于单个内皮细胞整合和转导来自周围环境的体液和生物力学刺激的能力。越来越多的证据强烈表明，生物力学刺激是内皮基因表达和这些细胞在几种病理生理条件下表现出的功能表型的关键决定因素。在此，我们讨论内皮细胞在脉管系统内不断暴露的生物力学力的类型，解释这些生物力学刺激如何充当内皮功能的调节剂，并讨论越来越多的证据表明“动脉粥样硬化保护”或“动脉粥样硬化倾向”血液动力学环境可以通过内皮转录程序的差异调节成为动脉粥样硬化形成的重要致病因素。
The functional phenotypic plasticity of the vascular endothelium relies on the ability of individual endothelial cells to integrate and transduce both humoral and biomechanical stimuli from their surrounding environments. Increasing evidence strongly suggests that biomechanical stimulation is a critical determinant of endothelial gene expression and the functional phenotypes displayed by these cells in several pathophysiological conditions. Herein we discuss the types of biomechanical forces that endothelial cells are constantly exposed to within the vasculature, explain how these biomechanical stimuli serve as regulators of endothelial functionanddiscuss the increasing evidence that “atherosclerosis-protective” or “atherosclerosis-prone” haemodynamic environments can beimportant causative factors for atherogenesis via the differential regulation of endothelial transcriptional programmes.