Concentration dependency of ethanol elimination rates in baboons: effect of chronic alcohol consumption.
Concentration dependency of ethanol elimination rates in baboons: effect of chronic alcohol consumption.
复制标题
狒狒乙醇消除率的浓度依赖性：长期饮酒的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
C. Lieber
中科院分区：
文献类型：
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作者：
P. Pikkarainen;C. Lieber
通过使用恒定的乙醇输注，以保持血液中的乙醇在三个不同的水平，5，10，和50 mM的乙醇消除率进行了测量，在7狒狒喂酒精2- 7年（和他们的控制）。乙醇消除率显着更快的血液乙醇水平为50 mM比在10或5 mM的酒精喂养和对照动物。50 mM和5 mM浓度之间的差异在酒精喂养的动物中为36%，在对照动物中为25%。在长期喂食乙醇的狒狒中，50 mM乙醇的消除速率显著快于配对喂食对照组。（179 +/- 10.0 mg/kg/hr vs 144 +/- 9.8）和10 mM（148 +/- 4.1对114 +/- 8.2），但在5 mM时并非如此。即使考虑到肝外损失，这些差异不能仅仅用通过低Km醇脱氢酶途径消除乙醇来解释，并且这些观察结果表明，非ADH系统显著有助于体内乙醇消除，特别是在酒精喂养的狒狒中。
Ethanol elimination rates were measured in 7 baboons fed alcohol for 2--7 yr (and their controls) by using a constant ethanol infusion to maintain blood ethanol at three different levels; 5, 10, and 50 mM. Ethanol elimination rates were significantly faster at a blood ethanol level of 50 mM than at 10 or 5 mM in both alcohol-fed and control animals. The difference between 50 mM and 5 mM concentration was 36% in alcohol-fed and 25% in control animals. In baboons fed ethanol chronically, the ethanol elimination rates were significantly faster than in pair-fed controls at 50 mM (179 +/- 10.0 mg/kg/hr versus 144 +/- 9.8) and at 10 mM (148 +/- 4.1 versus 114 +/- 8.2), but not at 5 mM. Even if one takes into account the extrahepatic losses, these differences cannot be explained solely by the elimination of ethanol through the low Km alcohol dehydrogenase pathway, and these observations indicate that a non-ADH system significantly contributes to ethanol elimination in vivo, especially in alcohol-fed baboons.