A strong heritability of psoriatic arthritis over four generations-the Reykjavik Psoriatic Arthritis Study
A strong heritability of psoriatic arthritis over four generations-the Reykjavik Psoriatic Arthritis Study
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DOI：
10.1093/rheumatology/kep243
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发表时间：
2009-11-01
期刊：
影响因子：
5.5
通讯作者：
Gudbjornsson, Bjorn
中科院分区：
文献类型：
--
作者：
Karason, Ari;Love, Thorvardur Jon;Gudbjornsson, Bjorn
目标。我们研究了在冰岛雷克雅未克的PsA患病率，基于人群的队列，并使用冰岛家谱数据库，我们估计了跨越五代的风险比（FIR）。雷克雅未克所有220名已知患有PsA的冰岛人的国民身份证号码与家谱数据库相关联。在PsA病例的一级亲属（FDRs）至第五级亲属中估计PsA发展的rr。计算了PsA的亲缘关系系数（KC）。对照人群分别为每个先证者1000组和10000组匹配的冰岛受试者。PsA患者四度亲属的FIR分别为39、12、3.6和2.3 (P值均< 0.0001)，反映了较强的遗传成分，而五度亲属的FIR为1.2 （P=0.236）。前7例被排除的减数眼的KCs分别为5.0、3.4、1.7、1.3、1.0、0.8和0.7 (p值均< 0.0001)，证实存在家族性风险。冰岛雷克雅未克的PsA患者彼此之间的相关性明显高于随机抽样的对照受试者。这与之前的报告一致，但目前的研究考察了更多远亲个体的遗传。这些发现表明，除了PsA中强大而复杂的遗传成分外，还有重要的环境贡献。
Objective. We have studied the prevalence of PsA in Reykjavik, Iceland, in a population-based cohort, and using the Icelandic genealogy database we have estimated the risk ratio (FIR) spanning five generations.Methods. The national identification numbers of all 220 living Icelanders in Reykjavik known to have PsA were linked with the genealogy database. RRs for developing PsA were estimated in first-degree relatives (FDRs) to fifth-degree relatives of PsA cases. The kinship coefficient (KC) for PsA was also calculated. The control populations were 1000 and 10000 sets of matched Icelandic subjects for each proband, respectively.Results. FDRs to fourth-degree relatives of patients with PsA had FIRS of 39, 12, 3.6 and 2.3, respectively (all P-values < 0.0001), reflecting a strong genetic component, whereas the fifth-degree relatives had an FIR of 1.2 (P=0.236). KCs of 5.0, 3.4, 1.7, 1.3, 1.0, 0.8 and 0.7 were observed for the first seven excluded meioses (all P-values < 0.0001), confirming the familial risk.Conclusions. Patients with PsA in Reykjavik, Iceland, are significantly more related to each other than to randomly sampled control subjects. This is in agreement with previous reports, but the present study examines the inheritance in more distantly related individuals. These findings indicate that in addition to a strong and complex genetic component in PsA, there is an important environmental contribution.