Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
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DOI：
10.1111/j.1365-2249.2004.02599.x
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发表时间：
2004-11-01
影响因子：
4.6
通讯作者：
Tilg, H
中科院分区：
文献类型：
--
作者：
Ludwiczek, O;Vannier, E;Tilg, H
白细胞介素（IL）-1是炎症性肠病（IBD）发病机制中的关键介质。天然存在的IL-1调节剂包括IL-1受体拮抗剂（IL-1 Ra）、IL-1可溶性受体I型（IL-1 sRI）、IL-1 sRII和IL-1受体辅助蛋白（AcP）。IBD中IL-1可溶性受体的全身和粘膜水平仍然未知。血浆或结肠组织从185名连续的克罗恩病（CD）或溃疡性结肠炎（UC）的结肠炎患者和52名对照受试者获得。评估血浆和结肠外植体培养物上清液的IL-1 α、IL-1 β、IL-1 Ra、IL-1 sRI和IL-1 sRII。UC患者的血浆IL-1 Ra水平（+93%）高于健康受试者。未检测到IL-1 α和IL-1 β。CD（-10%）和UC（-9%）中的IL-1 sRII水平略低，而CD（+28%）中的IL-1 sRI水平仅升高。血浆IL-1 sRI水平与血浆IL-1 sRI水平呈正相关（P
Interleukin (IL)-1 is a key mediator in the pathogenesis of inflammatory bowel disease (IBD). Naturally occurring IL-1 modulators include IL-1 receptor antagonist (IL-1Ra), IL-1 soluble receptor Type I (IL-1sRI), IL-1sRII and IL-1 receptor accessory protein (AcP). Systemic and mucosal levels of IL-1 soluble receptors remain unknown in IBD. Plasma or colonic tissues were obtained from 185 consecutive unselected patients with Crohn's disease (CD) or ulcerative colitis (UC) and from 52 control subjects. Plasma and colonic explant culture supernatants were assessed for IL-1alpha, IL-1beta, IL-1Ra, IL-1sRI and IL-1sRII. Plasma IL-1Ra levels were higher in UC (+93%) than in healthy subjects. IL-1alpha and IL-1beta were not detected. IL-1sRII levels were marginally lower in CD (-10%) and UC (-9%), whereas IL-1sRI levels were elevated in CD (+28%) only. Plasma IL-1sRI levels correlated positively (P