Alcohol consumption and risk of type 2 diabetes among older women
Alcohol consumption and risk of type 2 diabetes among older women
复制标题
DOI：
10.2337/diacare.28.12.2933
复制
发表时间：
2005-12-01
期刊：
影响因子：
16.2
通讯作者：
Bots, ML
中科院分区：
文献类型：
--
作者：
Beulens, JWJ;Stolk, RP;Bots, ML
目的-这项研究旨在调查饮酒和老年妇女2型糖尿病之间的关系。研究设计和方法-在1993年和1997年之间，16，330名年龄在49-70岁且无糖尿病的女性参加了一项荷兰的Prophylax-EPIC研究。（欧洲癌症与营养前瞻性研究）队列，随访6.2年（范围0.1-10.1）。在登记时，妇女填写调查问卷和血液样本收集。结果-在随访期间，760例2型糖尿病被记录。观察到饮酒与2型糖尿病风险之间存在线性负相关（P = 0.007），调整了潜在的混杂因素。与戒酒者相比，2型糖尿病的风险比为0.86（95% CI 0.66-1.12）每周饮酒5-30 g的女性，0.66（0.48-0.91），对于每周30-70 g，0.91（0.67-1.24），对于每周70-140 g，0.64（0.44-0.93），对于每周140-210 g，和0.69（0.47-1.02），对于每周> 210 g酒精。饮料类型没有影响这种关联。终身饮酒与2型糖尿病在一个U形Fashions.CONCLUSIONS -我们的研究结果支持的证据表明，2型糖尿病的风险降低与适度饮酒，并扩大这一人口的老年妇女。
OBJECTIVE - This study aimed to investigate the relation between alcohol consumption and type 2 diabetes among older women.RESEARCH DESIGN AND METHODS- Between 1993 and 1997, 16,330 women aged 49-70 years and free from diabetes were enrolled in one of the Dutch Prospect-EPIC ( European Prospective Study Into Cancer and Nutrition) cohorts and followed for 6.2 years (range 0.1-10.1). At enrollment, women filled in questionnaires and blood samples were collected.RESULTS - During follow-up, 760 cases of type 2 diabetes were documented. A linear inverse association (P = 0.007) between alcohol consumption and type 2 diabetes risk was observed, adjusting for potential confounders. Compared with abstainers, the hazard ratio for type 2 diabetes was 0.86 (95% CI 0.66-1.12) for women consuming 5-30 g alcohol per week, 0.66 (0.48-0.91) for 30-70 g per week, 0.91 (0.67-1.24) for 70-140 g per week, 0.64 (0.44-0.93) for 140-210 g per week, and 0.69 (0.47-1.02) for > 210 g alcohol per week. Beverage type did not influence this association. Lifetime alcohol consumption was associated with type 2 diabetes in a U-shaped Fashion.CONCLUSIONS - our findings support the evidence of a decreased risk of type 2 diabetes with moderate alcohol consumption and expand this to a population of older women.