Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.
Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.
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DOI：
10.1002/adsc.201500316
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发表时间：
2015-05-26
影响因子：
5.4
通讯作者：
Berkowitz DB
中科院分区：
文献类型：
--
作者：
Applegate GA;Berkowitz DB
在过去的二十年中，前沿合成有机化学和过程化学领域以及不对称有机/有机金属方法和酶方法之间的串扰增加了立体控制合成。这篇综述强调了脱氢酶在这一努力中的特别有利的作用，重点是动态还原动力学分辨率（DYRKR）来“脱羧”构建块，通常在这样做时设置两个立体中心。概述了这种脱氢酶介导的过程的范围和局限性，以及酶促DYRKR进化的未来可能性。
Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry and have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to “deracemize” building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.