Hypermethylation of FOXD3 suppresses cell proliferation, invasion and metastasis in hepatocellular carcinoma
Hypermethylation of FOXD3 suppresses cell proliferation, invasion and metastasis in hepatocellular carcinoma
复制标题
FOXD3高甲基化抑制肝细胞癌细胞增殖、侵袭和转移
DOI：
10.1016/j.yexmp.2015.06.017
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发表时间：
2015-10-01
影响因子：
3.6
通讯作者：
Liang, Li
中科院分区：
文献类型：
--
作者：
He, Guoyang;Hu, Shuiwang;Liang, Li
叉头盒D3 （FOXD3）作为一种转录抑制因子，在多种肿瘤的发生发展中起着重要作用。然而，FOXD3的功能和甲基化状态在肝细胞癌（HCC）的进展中仍然未知。在本研究中，我们发现FOXD3在HCC组织中降低，并与HCC患者的分化、AFP和生存不良相关(p
As a transcriptional repressor, forkhead box D3 (FOXD3) plays an important role in tumorigenesis and progression of several tumors. However, the function and methylation status of FOXD3 remain unknown in the progression of hepatocellular carcinoma (HCC). In this study, we found that FOXD3 was decreased in HCC tissues and correlated with differentiation, AFP and poor survival of HCC patients (p