Oscillatory subthalamic nucleus activity is modulated by dopamine during emotional processing in Parkinson's disease
Oscillatory subthalamic nucleus activity is modulated by dopamine during emotional processing in Parkinson's disease
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DOI：
10.1016/j.cortex.2014.02.019
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发表时间：
2014-11-01
期刊：
影响因子：
3.6
通讯作者：
Kuehn, Andrea A.
中科院分区：
文献类型：
--
作者：
Huebl, Julius;Spitzer, Bernhard;Kuehn, Andrea A.
帕金森病 (PD) 中的多巴胺能去神经不仅会导致运动缺陷，还会导致抑郁、缺乏动力和冷漠。这些症状可以通过多巴胺能治疗来逆转，这甚至可能导致一些帕金森病患者的享乐基调增加。在这里，我们测试了多巴胺对情绪处理的影响，以 28 名接受深部脑刺激的 PD 患者底丘脑核 (STN) 局部场电位 (LFP) 活动的变化为指标。在进行情感图片观看任务期间，在服用左旋多巴（ON 组）或过夜停药（OFF 组）后记录 STN 的 LFP 活动。从国际情感图片系统中选择中性的、情绪激动的愉快和不愉快的刺激。我们发现α频带反应的双重解离取决于多巴胺状态和刺激价：多巴胺增强了愉快刺激的处理，而不愉快刺激期间的激活则减少，如α频带中的去同步程度所指示的。这种模式在关闭状态下发生逆转，并且在非抑郁性 PD 患者亚组中更为明显。此外，我们发现早期伽马带随着不愉快的刺激而增加，这种刺激发生在开启而非关闭药物时，并且与刺激唤醒相关。晚期 STN α 带减少被认为代表了感觉信息的主动处理。我们的研究结果支持这样的观点，即多巴胺在帕金森病晚期刺激评估过程中增强与接近相关的过程。早期伽马带反应可能代表注意力增加的局部编码，其随着刺激唤醒的函数而变化。 (C) 2014 Elsevier Ltd. 保留所有权利。
Dopaminergic denervation in Parkinson's disease (PD) leads to motor deficits but also depression, lack of motivation and apathy. These symptoms can be reversed by dopaminergic treatment, which may even lead to an increased hedonic tone in some patients with PD. Here, we tested the effects of dopamine on emotional processing as indexed by changes in local field potential (LFP) activity of the subthalamic nucleus (STN) in 28 PD patients undergoing deep brain stimulation. LFP activity from the STN was recorded after the administration of levodopa (ON group) or after overnight withdrawal of medication (OFF group) during presentation of an emotional picture-viewing task. Neutral and emotionally arousing pleasant and unpleasant stimuli were chosen from the International Affective Picture System. We found a double dissociation of the alpha band response depending on dopamine state and stimulus valence: dopamine enhanced the processing of pleasant stimuli, while activation during unpleasant stimuli was reduced, as indexed by the degree of desynchronization in the alpha frequency band. This pattern was reversed in the OFF state and more pronounced in the subgroup of non-depressed PD patients. Further, we found an early gamma band increase with unpleasant stimuli that occurred when ON but not OFF medication and was correlated with stimulus arousal. The late STN alpha band decrease is thought to represent active processing of sensory information. Our findings support the idea that dopamine enhances approach-related processes during late stimulus evaluation in PD. The early gamma band response may represent local encoding of increased attention, which varies as a function of stimulus arousal. (C) 2014 Elsevier Ltd. All rights reserved.