Investigation of a candidate gene, environment, and G x E interaction using case-control and case-parent study designs.
Investigation of a candidate gene, environment, and G x E interaction using case-control and case-parent study designs.
复制标题
使用病例对照和病例亲本研究设计研究候选基因、环境和 G x E 相互作用。
DOI：
10.1002/gepi.2001.21.s1.s843
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Genin,E
中科院分区：
文献类型：
--
作者：
Norris,JM;Selinger-Leneman,H;Genin,E
We investigated the independent contributions of a candidate gene and an environmental factor, and the presence of gene×environment (G×E) interaction, in the etiology of a disease in the Genetic Analysis Workshop (GAW) 12 problem 2 simulated data using a two‐stage approach utilizing both case‐control and case‐parent study designs. Using the case‐control design, several SNPs within candidate gene 1 (CG1) and environmental factor 1 (dichotomized using the 75thpercentile as a cut‐off) (EXP) were independently associated with disease status, in models adjusted for age and sex. We found evidence of gene×environment (G×E) interaction between EXP and two single‐nucleotide polymorphisms (SNPs) within CGI using the case‐control design. Using the case‐parent study design in the same population, we detected association between SNPs within CG1 and disease, but no G×E interaction was detected. © 2001 Wiley‐Liss, Inc.
