The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle
The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle
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DOI：
10.1038/jid.2009.192
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发表时间：
2010-01-01
影响因子：
6.5
通讯作者：
Schweizer, Juergen
中科院分区：
文献类型：
--
作者：
Langbein, Lutz;Yoshida, Hiroshi;Schweizer, Juergen
我们研究了54种角蛋白中52种在胡须髓质中的表达。我们发现，不仅有12种毛发角蛋白，出乎意料的是，还有12种上皮角蛋白可能在髓质细胞中表达。后者包括角蛋白也存在于外、内根鞘和伴生层中。角蛋白K5、K14、K17、K25、K27、K28和K75定义了“前髓质”，由靠近上真皮乳头的细胞组成。除K6、K16、K7、K19和K80外，所有髓前上皮角蛋白以及12种毛发角蛋白继续在髓质内表达。除了这种细胞角蛋白共表达的独特特征外，角蛋白模式本身在单个髓质细胞中是高度可变的。值得注意的是，上皮和毛发角蛋白在异源二聚体和IF的形成中表现出高度混杂，这也包括IF束中角蛋白链的相互作用。我们还在髓柱内发现了皮层细胞。这些细胞表现出真正皮层细胞的所有特性，包括其致密IF束的一种特殊类型的角蛋白异质性。在角蛋白表达谱和角蛋白数量方面，髓质细胞不同于毛囊的所有其他细胞或任何其他上皮细胞。
We have investigated the expression of 52 of the 54 keratins in beard hair medulla. We found that not only 12 hair keratins but, unexpectedly, also 12 epithelial keratins are potentially expressed in medulla cells. The latter comprise keratins also present in outer- and inner-root sheaths and in the companion layer. Keratins K5, K14, K17, K25, K27, K28, and K75 define a "pre-medulla,'' composed of cells apposed to the upper dermal papilla. Besides K6, K16, K7, K19, and K80, all pre-medullary epithelial keratins continue to be expressed in the medulla proper, along with the 12 hair keratins. Besides this unique feature of cellular keratin co-expression, the keratin pattern itself is highly variable in individual medulla cells. Remarkably, both epithelial and hair keratins behave highly promiscuously with regard to heterodimer- and IF formation, which also includes keratin chain interactions in IF bundles. We also identified cortex cells within the medullary column. These exhibit all the properties of genuine cortex cells, including a particular type of keratin heterogeneity of their compact IF bundles. In both keratin expression profile and keratin number, medulla cells are distinct from all other cells of the hair follicle or from any other epithelium.