Gamma/delta T-cell posttransplantation lymphoproliferative disorder primarily in the spleen.
Gamma/delta T-cell posttransplantation lymphoproliferative disorder primarily in the spleen.
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γ/δ T 细胞移植后淋巴增殖性疾病主要发生在脾脏。
DOI：
10.1093/ajcp/102.3.310
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发表时间：
1994
影响因子：
3.5
通讯作者：
Hanson,CA
中科院分区：
文献类型：
--
作者：
Ross,CW;Schnitzer,B;Sheldon,S;Braun,DK;Hanson,CA
一例31岁的肾移植受者在移植3年后出现了一种不寻常的t细胞增生性疾病。肿瘤累及脾脏，未伴有肝肿大、淋巴结病变或明显的骨髓累及。脾切除术后外周血受累。免疫表型上，肿瘤细胞在表面膜上表达CD2、CD3、CD7、CD16、CD45、CD56和γ/δ t细胞受体。肿瘤细胞表面膜CD4、CD5、CD8均呈阴性。包括爱泼斯坦-巴尔病毒、人类t细胞嗜淋巴病毒-1、人类免疫缺陷病毒和人类疱疹病毒-6在内的病毒的血清学和/或DNA分析均为阴性。细胞遗传学发现包括染色体7p15的易位断点，与t细胞受体γ链位点的参与一致。虽然有报道称γ/δ t细胞淋巴瘤倾向于肝脾定位，但这是第一例在移植后免疫抑制的情况下被充分记录的病例。
A 31-year-old renal transplant recipient developed an unusual T-cell lymphoproliferative disorder 3 years after transplantation. The neoplasm involved the spleen, without concomitant hepatomegaly, lymphadenopathy, or obvious bone marrow involvement. Peripheral blood involvement developed after splenectomy. Immunophenotypically, the neoplastic cells expressed CD2, CD3, CD7, CD16, CD45, CD56, and theγ/δT-cell receptor on the surface membrane. The neoplastic cells were negative for surface membrane CD4, CD5, and CD8. Serologic and/or DNA analyses for viruses, including Epstein-Barr virus, human T-cell lymphotropic virus-1, human immunodeficiency virus, and human herpesvirus-6, were negative. Cytogenetic findings included a translocation breakpoint at chromosome 7p15, consistent with involvement of the T-cell receptorγ-chain locus. Althoughγ/δT-cell lymphomas have been reported to have a predilection for hepatosplenic localization, this is the first well-documented case to be described in the setting of posttransplantation immunosuppression.