Surface antigens of Biomphalaria glabrata (Gastropoda) hemocytes: evidence for linkage-independence of some hemolymph-like surface antigens and Con A receptor-bearing macromolecules.
Surface antigens of Biomphalaria glabrata (Gastropoda) hemocytes: evidence for linkage-independence of some hemolymph-like surface antigens and Con A receptor-bearing macromolecules.
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Biomphalaria glabrata（腹足纲）血细胞的表面抗原：一些血淋巴样表面抗原和带有 Con A 受体的大分子的连锁独立性的证据。
DOI：
10.1016/0022-2011(83)90197-0
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发表时间：
1983
影响因子：
3.4
通讯作者：
Davis,CD
中科院分区：
文献类型：
--
作者：
Yoshino,TP;Davis,CD
The structural relationship between hemolymph-like surface antigens and concanavalin A (Con A)-reactive macromolecules on circulating hemocytes ofBiomphalaria glabratawas assessed using a double-ligand labeling method. It was determined that Con A-induced clearance of its own receptor complexes resulted in a significant reduction, but of complete elimination, of hemolymph-like antigens, i.e., antigens cross-reactive with an anti-B. glabratahemolymph antiserum, suggesting the presence of at least two separate antigenic populations with anti-hemolymph reactivity; one group structurally linked and another group structurally independent of Con A-binding membrane components. The latter group of surface antigens appears to be (1) chemically related to the higher-molecular-weight hemolymph components, most probably hemoglobin, (2) Pronase resistant, and (3) partially composed of a subpopulation of cryptic (hidden) cross-reacting antigens uncovered at the cell surface as a consequence of Con A-receptor clearance. Results of this study demonstrate not only that individual hemocytes ofB. glabratamay possess different populations of hemolymph-like antigens, but also that the interaction between some membrane components and appropriate ligands (e.g., carbohydrate-binding lectins) could result in a modulation in expression of other groups of surface antigens.
