cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.
cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.
复制标题
从凋亡人类 T 细胞系中克隆 NGFI-B/nur77 相关转录因子的 cDNA。
DOI：
10.4049/jimmunol.154.8.3871
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发表时间：
1995
影响因子：
4.4
通讯作者：
T. Watanabe
中科院分区：
文献类型：
--
作者：
T. Okabe;R. Takayanagi;K. Imasaki;M. Haji;H. Nawata;T. Watanabe
人T淋巴细胞系PEER在PMA和钙离子载体存在下通过凋亡死亡。从凋亡的PEER细胞中克隆了一个新的基因TINUR。TINUR基因的表达在T细胞Ag受体复合物交联后1小时内诱导。TINUR属于类固醇受体超家族的NGFI-B/nur 77家族，并且是孤儿受体。TINUR与NGFI-B/nur 77结合相同的DNA序列。我们还提出NGFI-B/nur 77家族可以分为两个亚型。
A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore. A new gene, TINUR, was cloned from apoptotic PEER cells. The expression of the TINUR gene is induced within 1 h after the cross-linking of the T cell Ag receptor complex. TINUR belongs to the NGFI-B/nur77 family of the steroid receptor superfamily and is an orphan receptor. TINUR binds to the same DNA sequence as NGFI-B/nur77. We also propose that the NGFI-B/nur77 family can be classified into two subtypes.