West Nile Virus in Brazil.
West Nile Virus in Brazil.
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DOI：
10.3390/pathogens10070896
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发表时间：
2021-07-15
期刊：
影响因子：
--
通讯作者：
Alcantara LCJ
中科院分区：
文献类型：
--
作者：
Costa ÉA;Giovanetti M;Silva Catenacci L;Fonseca V;Aburjaile FF;Chalhoub FLL;Xavier J;Campos de Melo Iani F;da Cunha E Silva Vieira MA;Freitas Henriques D;Medeiros DBA;Guedes MIMC;Senra Álvares da Silva Santos B;Gonçalves Silva AS;de Pino Albuquerque Maranhão R;da Costa Faria NR;Farinelli de Siqueira R;de Oliveira T;Ribeiro Leite Jardim Cavalcante K;Oliveira de Moura NF;Pecego Martins Romano A;Campelo de Albuquerque CF;Soares Feitosa LC;Martins Bayeux JJ;Bertoni Cavalcanti Teixeira R;Lisboa Lobato O;da Costa Silva S;Bispo de Filippis AM;Venâncio da Cunha R;Lourenço J;Alcantara LCJ
西尼罗河病毒（WNV）于2019年在巴西首次测序，当时它是从圣埃斯皮里图州的一匹马中分离出来的。尽管有多项研究报告了自2004年以来的血清学证据，但西尼罗河病毒仍然是监测和公共卫生的低优先事项，因此对其基因组多样性，进化和在该国的传播仍知之甚少。研究方法：诊断分析，纳米孔测序，系统发育推断和流行病学建模的组合在这里用来提供一个整体概述什么是已知的西尼罗河病毒在巴西。结果如下：我们报告了新的遗传证据西尼罗河病毒循环在南部（米纳斯吉拉斯，圣保罗）和东北部（皮奥伊）州分离的马红细胞。一个新的，气候知情的理论观点的潜在传播西尼罗河病毒在全国各地突出了皮奥伊州作为特别相关的西尼罗河病毒流行病学在巴西，虽然它不拒绝可能在其他国家的流通。结论：我们的结果表明，现有数据的稀缺性，虽然有足够的证据证明该病毒的传播和持久性，但其局部进化，流行病学和活动仍然未知。我们主张转向积极监测，以确保为未来可能蔓延到人类的流行病做好充分准备。
Background: West Nile virus (WNV) was first sequenced in Brazil in 2019, when it was isolated from a horse in the Espírito Santo state. Despite multiple studies reporting serological evidence suggestive of past circulation since 2004, WNV remains a low priority for surveillance and public health, such that much is still unknown about its genomic diversity, evolution, and transmission in the country. Methods: A combination of diagnostic assays, nanopore sequencing, phylogenetic inference, and epidemiological modeling are here used to provide a holistic overview of what is known about WNV in Brazil. Results: We report new genetic evidence of WNV circulation in southern (Minas Gerais, São Paulo) and northeastern (Piauí) states isolated from equine red blood cells. A novel, climate-informed theoretical perspective of the potential transmission of WNV across the country highlights the state of Piauí as particularly relevant for WNV epidemiology in Brazil, although it does not reject possible circulation in other states. Conclusion: Our output demonstrates the scarceness of existing data, and that although there is sufficient evidence for the circulation and persistence of the virus, much is still unknown on its local evolution, epidemiology, and activity. We advocate for a shift to active surveillance, to ensure adequate preparedness for future epidemics with spill-over potential to humans.
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影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ
影响因子：
11.8
作者：
Morales MA;Barrandeguy M;Fabbri C;Garcia JB;Vissani A;Trono K;Gutierrez G;Pigretti S;Menchaca H;Garrido N;Taylor N;Fernandez F;Levis S;Enría D
通讯作者：
Enría D
DOI：
10.1590/0074-02760180332
发表时间：
2019-01-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Martins, Lívia Caricio;Silva, Eliana Vieira Pinto da;Vasconcelos, Pedro Fernando da Costa
通讯作者：
Vasconcelos, Pedro Fernando da Costa
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
14.9
作者：
Katoh K;Kuma K;Toh H;Miyata T
通讯作者：
Miyata T