Novel synthesis of 2-trichloromethyl-4-vinyloxazoline and its derivatization by ring cleavage reactions*
Novel synthesis of 2-trichloromethyl-4-vinyloxazoline and its derivatization by ring cleavage reactions*
复制标题
2-三氯甲基-4-乙烯基恶唑啉的新合成及其开环反应衍生*
DOI：
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发表时间：
2012
影响因子：
1.5
通讯作者：
A. Jirgensons
中科院分区：
文献类型：
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作者：
L. Grigorjeva;A. Maleckis;K. Klimovica;M. Skvorcova;N. Ivdra;G. Leitis;A. Jirgensons
以3-丁烯-1，2-二醇为原料，经刘易斯酸催化环合反应合成了2-三氯甲基-4-乙烯基恶唑啉。2-三氯甲基-4-乙烯基恶唑啉的衍生化潜力通过与水、氢溴酸、盐酸和乙酸的开环反应得到烯丙基胺衍生物来证明。
A novel efficient and eco-friendly method for the synthesis of 2-trichloromethyl-4-vinyloxazoline is presented that involves Lewis acid-catalyzed cyclization of bisimidate derived from but-3-ene-1,2-diol. The derivatization potential of 2-trichloromethyl-4-vinyloxazoline is demonstrated by ring opening reactions with water, hydrobromic acid, hydrochloric acid, and acetic acid leading to allylamine derivatives.