The Application of Sheet Technology in Cartilage Tissue Engineering
The Application of Sheet Technology in Cartilage Tissue Engineering
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片材技术在软骨组织工程中的应用
DOI：
10.1089/ten.teb.2015.0189
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发表时间：
2016
影响因子：
6.4
通讯作者：
Fu Wei
中科院分区：
文献类型：
--
作者：
Ge Yang;Gong Yi Yi;Xu Zhiwei;Lu Yanan;Fu Wei
考虑到成人无血管结构的软骨组织自我更新能力非常有限，且传统手术治疗方法存在瓶颈，软骨组织工程开始成为软骨修复和再生过程中一种有前景、甚至是必不可少的替代方法。组织工程的最新进展实现了治疗软骨疾病的更可行策略的开发。其中，细胞片层技术在角膜和食道等再生区域显示出巨大的临床潜力，并且由于其不使用支架且不破坏培养细胞分泌的基质，越来越多地被认为是重建软骨组织的潜在方法。用于软骨组织工程的脱细胞基质片技术，采用三明治模型，可以巧妙地克服传统脱细胞块中出现的缺点，即由于非纳米孔结构，细胞经常被阻止迁移。具有模仿天然软骨基质的纳米结构的静电纺丝片材提供一定程度的控制和操纵，使其在软骨组织工程中具有吸引力并广泛使用。在这篇综述中，我们重点关注利用这些新颖且有前途的片材技术来构建具有实用和有益功能的软骨组织。
Cartilage tissue engineering started to act as a promising, even essential alternative method in the process of cartilage repair and regeneration, considering adult avascular structure has very limited self-renewal capacity of cartilage tissue in adults and a bottle-neck existed in conventional surgical treatment methods. Recent progressions in tissue engineering realized the development of more feasible strategies to treat cartilage disorders. Of these strategies, cell sheet technology has shown great clinical potentials in the regenerative areas such as cornea and esophagus and is increasingly considered as a potential way to reconstruct cartilage tissues for its non-use of scaffolds and no destruction of matrix secreted by cultured cells. Acellular matrix sheet technologies utilized in cartilage tissue engineering, with a sandwich model, can ingeniously overcome the drawbacks that occurred in a conventional acellular block, where cells are often blocked from migrating because of the non-nanoporous structure. Electrospun-based sheets with nanostructures that mimic the natural cartilage matrix offer a level of control as well as manipulation and make them appealing and widely used in cartilage tissue engineering. In this review, we focus on the utilization of these novel and promising sheet technologies to construct cartilage tissues with practical and beneficial functions.