Quantitative analysis of CSF flow dynamics using MRI in normal pressure hydrocephalus.
Quantitative analysis of CSF flow dynamics using MRI in normal pressure hydrocephalus.
复制标题
使用 MRI 对正常压力脑积水的脑脊液流动动力学进行定量分析。
DOI：
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发表时间：
1998
期刊：
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通讯作者：
T. Matsumoto
中科院分区：
文献类型：
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作者：
M. Mase;Kazuo Yamada;Tatsuo Banno;T. Miyachi;S. Ohara;T. Matsumoto
为了明确正常压力脑积水（NPH）中脑脊液（CSF）的流动动力学，采用回顾性心脏门控相衬电影磁共振（MR）成像技术测量蛛网膜下腔出血后NPH（SAH-NPH组，n=17）、特发性NPH（1-NPH组，n=17）患者导水管内CSF的定量流速。 2）、无症状脑室扩张或脑萎缩（VD组，n=7）和健康志愿者（对照组，n=19）。在分流手术期间，还测量了 6 名 SAH-NPH 组的颅内压 (ICP) 和压力容积反应 (PVR)。 SAH-NPH 组导水管中的最大 CSF 流速 (Vmax) 显着大于对照组 (5.27 +/- 1.77, p < 0.001) 和 VD 组 (4.06 +/- 1.81, p < 0.005) (9.21 +/- 4.12 cm/sec, 平均值 +/- SD)。对照组和 VD 组之间的 Vmax 没有差异。 SAH-NPH 组 PVR 与脑脊液峰值流速呈正相关。这些结果表明SAH-NPH组脑脊液流速的变化可能是由于颅内顺应性的中度降低引起的。使用 MRI 进行的脑脊液流量研究有助于区分 NPH 与脑萎缩或无症状脑室扩张，并可估计颅内顺应性。
In order to clarify the flow dynamics of cerebrospinal fluid (CSF) in normal pressure hydrocephalus (NPH), a phase-contrast cine magnetic resonance (MR) imaging technique with retrospective cardiac gating was used to measure the quantitative flow velocity of CSF in the aqueduct in patients with NPH after subarachnoid hemorrhage (SAH-NPH group, n = 17), idiopathic NPH (1-NPH group, n = 2), asymptomatic ventricular dilatation or brain atrophy (VD group, n = 7) and healthy volunteers (control group, n = 19). Intracranial pressure (ICP) and pressure volume response (PVR) were also measured during the shunt operation in six of the SAH- NPH group. The maximum CSF flow velocity (Vmax) in the aqueduct was significantly larger in the SAH-NPH group (9.21 +/- 4.12 cm/sec, mean +/- SD) than in the control group (5.27 +/- 1.77, p < 0.001) and the VD group (4.06 +/- 1.81, p < 0.005). Vmax was not different between the control and VD groups. There was a positive correlation between the PVR and the peak CSF flow velocity in the SAH-NPH group. These findings suggest that the changes of CSF flow velocity in the SAH-NPH group might be caused by a moderate decrease of intracranial compliance. The CSF flow study using MRI is useful to differentiate NPH from brain atrophy or asymptomatic ventricular dilatation and also to estimate the intracranial compliance.