A Systematic Literature Review of the Burden of Respiratory Syncytial Virus and Health Care Utilization Among United States Infants Younger Than 1 Year.
A Systematic Literature Review of the Burden of Respiratory Syncytial Virus and Health Care Utilization Among United States Infants Younger Than 1 Year.
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对1岁以下的美国婴儿的呼吸道合胞病毒和医疗保健利用负担的系统文献回顾。
DOI：
10.1093/infdis/jiac201
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发表时间：
2022-08-15
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影响因子：
--
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--
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在医疗保健机构中，1岁以下美国婴儿的呼吸道合胞病毒（RSV）负担和医疗保健利用（HCU）尚未得到很好的表征。我们系统回顾了2000-2021年发表的RSV和细支气管炎研究（数据年，1979-2020）。结果包括RSV住院（RSVH）/细支气管炎住院率、急诊（艾德）/门诊（OP）访视率和RSV-/细支气管炎住院婴儿的重症监护室（ICU）入院率或机械通气（MV）使用率。使用标准工具确定研究质量。我们确定了141项良好/中等质量的研究。五项国家研究报告了年平均RSV感染率（范围从2006年6-11个月婴儿的11.6/1000/年到1997年0-2个月婴儿的50.1/1000/年）。两项国家研究提供了整个研究期间按初步诊断的RSVH率（范围，1997-1999年和1997-2000年分别为22.0-22.7/1000）。无国家艾德/OP数据可用。在11项非国家研究中，由于时间、人群（如早产儿）和地点的差异，RSVH发生率各不相同。一项国家研究报告称，1997-2012年，患有高风险合并症的RSVH婴儿的MV使用量是非高风险婴儿的5倍。观察到大量数据变异性。需要进行国家代表性研究以阐明RSV负荷和HCU。
The burden and health care utilization (HCU) of respiratory syncytial virus (RSV) in US infants aged <1 year across health care settings are not well characterized. We systematically reviewed studies of RSV and bronchiolitis published 2000–2021 (data years, 1979–2020). Outcomes included RSV hospitalization (RSVH)/bronchiolitis hospitalization rates, emergency department (ED)/outpatient (OP) visit rates, and intensive care unit (ICU) admissions or mechanical ventilation (MV) use among RSV-/bronchiolitis-hospitalized infants. Study quality was determined using standard tools. We identified 141 good-/fair-quality studies. Five national studies reported annual average RSVH rates (range, 11.6 per 1000 per year among infants aged 6–11 months in 2006 to 50.1 per 1000 per year among infants aged 0–2 months in 1997). Two national studies provided RSVH rates by primary diagnosis for the entire study period (range, 22.0–22.7 per 1000 in 1997–1999 and 1997–2000, respectively). No national ED/OP data were available. Among 11 nonnational studies, RSVH rates varied due to differences in time, populations (eg, prematurity), and locations. One national study reported that RSVH infants with high-risk comorbidities had 5-times more MV use compared to non–high-risk infants in 1997-2012. Substantial data variability was observed. Nationally representative studies are needed to elucidate RSV burden and HCU.
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影响因子：
4.2
作者：
Franklin, Jeremy A.;Anderson, Evan J.;Simoes, Eric A. F.
通讯作者：
Simoes, Eric A. F.
影响因子：
1.3
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Foote EM;Singleton RJ;Holman RC;Seeman SM;Steiner CA;Bartholomew M;Hennessy TW
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Hennessy TW
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3.6
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Ambrose, Christopher S.;Anderson, Evan J.;Groothuis, Jessie R.
通讯作者：
Groothuis, Jessie R.
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2
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Goldstein M;Krilov LR;Fergie J;Brannman L;Wade SW;Kong AM;Ambrose CS
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Ambrose CS
影响因子：
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作者：
Jafri, Hasan S.;Wu, Xionghua;Henrickson, Kelly J.
通讯作者：
Henrickson, Kelly J.