Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: The POLA study
Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: The POLA study
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DOI：
10.1167/iovs.05-1235
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发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Schalch, Wolfgang
中科院分区：
文献类型：
--
作者：
Delcourt, Cicile;Carriere, Isabelle;Schalch, Wolfgang
目的。在以人群为基础的眼科病理和年龄（POLA）研究中，评估血浆叶黄素、玉米黄质和其他类胡萝卜素与年龄相关性黄斑病变（ARM）和白内障风险的关系。视网膜照片按照国际分类进行分级。ARM的定义是晚期ARM（新生血管性ARM，地理萎缩）和/或与色素异常相关的软性模糊结节（> 125 μ m）和/或软性明显结节（> 125 μ m）的存在。根据晶状体混浊分类系统III，白内障分类是基于裂隙灯下的直接标准化晶状体检查。采用高效液相色谱法测定了899名受试者血浆类胡萝卜素含量。多因素调整后，血浆玉米黄质最高五分位数与降低ARM （OR = 0.07; 95% CI: 0.01-0.58-1 P，趋势= 0.005）、核性白内障（OR = 0.23-1 95% CI: 0.08-0.68； P，趋势= 0.003）和任何白内障（OR = 0.53; 95% CI: 0.31-0.89； P，趋势= 0.01）的风险显著相关。ARM与血浆叶黄素和zcaxanthin联合相关（OR = 0.21; 95% CI: 0.05 ~ 0.79； P为趋势= 0.01），且与血浆叶黄素有相关性（OR = 0.31; 95% CI: 0.09 ~ 1.07； P为趋势= 0.04），而白内障无相关性。在其他类胡萝卜素中，只有β -胡萝卜素与uncle at呈显著负相关。白内障，但没有膀胱癌。这些结果强烈提示黄酮类物质，特别是玉米黄质，对ARM和白内障具有保护作用。
PURPOSE. To assess the associations of plasma lutein and zeaxanthin and other carotenoids with the risk of age-related maculopathy (ARM) and cataract in the population-based Pathologies Oculaires Liees a l'Age (POLA) Study.METHODS. Retinal photographs were graded according to the international classification. ARM was defined by the presence of late ARM (neovascular ARM, geographic atrophy) and/or soft indistinct drusen (> 125 mu m) and/or soft distinct drusen (> 125 gm) associated with pigmentary abnormalities. Cataract classification was based on a direct standardized lens examination at the slit lamp, according to Lens Opacities Classification System III. Plasma carotenoids were measured by high-performance liquid chromatography (HPLC), in 899 subjects of the cohort.RESULTS. After multivariate adjustment, the highest quintile of plasma zeaxanthin was significantly associated with reduced risk of ARM (OR = 0.07; 95% CI: 0.01-0.58-1 P for trend = 0.005), nuclear cataract (OR = 0.23-1 95% CI: 0.08-0.68; P for trend = 0.003) and any cataract (OR = 0.53; 95% CI: 0.31-0.89; P for trend = 0.01). ARM was significantly associated with combined plasma lutein and zcaxanthin (OR = 0.21; 95% CI: 0.05-0.79; P for trend = 0.01), and tended to be associated with plasma lutein (OR = 0.31; 95% CI: 0.09-1.07; P for trend = 0.04), whereas cataract showed no such associations. Among other carotenoids, only beta-carotene showed a significant negative association with uncle at. cataract, but not ARM.CONCLUSIONS. These results are strongly suggestive of a protective role of the xanthophylls, in particular zeaxanthin, for the protection against ARM and cataract.