Idiopathic scoliosis. Mechanical properties of the respiratory system and the ventilatory response to carbon dioxide.
Idiopathic scoliosis. Mechanical properties of the respiratory system and the ventilatory response to carbon dioxide.
复制标题
特发性脊柱侧弯。
DOI：
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发表时间：
1975
影响因子：
15.9
通讯作者：
E. Kafer
中科院分区：
文献类型：
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作者：
E. Kafer
目的是检查脊柱侧凸（角度）和年龄对肺容量、呼吸系统弹性特性和对CO2的通气反应的影响。55例患者的平均年龄为25.4±SEM 2.5岁，平均角度为80±SEM 4.2。平均正负SEM预测肺容量为肺活量（VC）， 60.5正负2.7；总肺活量（TLC） 70±2.6；功能剩余容量（frc）， 79.3±3.2；剩余容积（RV）， 99.7±5.2。脊柱侧弯角度与TLC（-0.548）、预测TLC百分比（-0.547）、VC（-0.485）、预测VC百分比（-0.523）、FRC百分比（-0.533）、预测FRC百分比（-0.338）、RV百分比（-0.438）、预测RV百分比（-0.318）的相关系数均显著。总呼吸系统（Crs）的平均顺应性为0.049 l /cm H2O±SEM 0.004，胸壁（Ccw）的平均顺应性为0.080 l /cm H2O±SEM 0.012。Crs和Ccw与角度成反比（r-0.620和-0.721），与身高和体重成正比。平均deltaV/deltaPco2为1.32 l/ min /mm Hg (SEM 0.171)，平均deltaavt /deltaPco2为28.9 ml/mm Hg （SEM 3.64）。deltaV/deltaPco2与以下指标的相关系数为：高度0.499；VC 0.792;薄层色谱,0.632;AND Crs, 0.520；deltaTt/deltaPco2与以下值之间的高度为0.500；VC 0.878;薄层色谱,0.802;Crs为0.590。我们得出结论，体型和畸形是肺容量和呼吸系统机械特性的决定因素，这些变量是对CO2通气反应的大小和模式的主要因素。年龄与呼吸系统力学性能、deltaV/deltaPco2和deltaavt /deltaPco2的相关性不显著，但年龄与deltaV/deltaPco2和deltaavt /deltaPco2的几个导数之间的相关系数显著。
The aims were to examine the effects of scoliosis (angle), and age on lung volumes, elastic properties of the respiratory system, and the ventilatory response to CO2. The mean age of the 55 patients was 25.4 plus or minus SEM 2.5 yr, and the mean angle was 80 plus or minus SEM 4.2. The mean plus or minus SEM percent predicted lung volumes were vital capacity (VC), 60.5 plus or minus 2.7; total lung capacity (TLC), 70,2 plus or minus 2.6; functional residual capacity (frc), 79.3 plus or minus 3.2; and residual volume (RV), 99.7 plus or minus 5.2. The correlation coefficients between the angle of scoliosis and each of the following were significant: TLC (-0.548), percent predicted TLC (-0.547), VC (-0.485), percent predicted VC (-0.523), FRC (-0.533), percent predicted FRC (-0.338), RV (-0.438), and percent predicted RV (-0.318). The mean compliance of the total respiratory system (Crs) was 0.049 litter/cm H2O plus or minus SEM 0.004, and the mean compliance of the chest wall (Ccw) was 0.080 liter/cm H2O plus or minus SEM 0.012. The Crs and Ccw were inversely proportional to the angle (r-0.620 and -0.721) and directly proportional to the height and the weight. The mean deltaV/deltaPco2 was 1.32 liter/min per mm Hg (SEM 0.171), and the mean deltaVt/deltaPco2 was 28.9 ml/mm Hg (SEM 3.64). The correlation coefficients between deltaV/deltaPco2 and the following were height, 0.499; VC, 0.792; TLC, 0.632; AND Crs, 0.520; and between the deltaTt/deltaPco2 and the following were height, 0.500; VC, 0.878; TLC, 0.802; and Crs, 0.590. We conclude that body size and the deformity were the determinants of the lung volumes and the mechanical properties of the respiratory system, and that these variables were the major factors in both the magnitude and pattern of the ventilatory response to CO2. The correlations between age and the mechanical properties of the respiratory sytem, deltaV/deltaPco2, and deltaVt/deltaPco2, were not significant, but the correlation coefficients between age and several of the derivatives of deltaV/deltaPco2 and deltaVt/deltaPco2 were significant.