Alignment of Cortical Vessels viewed through the Surgical Microscope with Preoperative Imaging to Compensate for Brain Shift.
Alignment of Cortical Vessels viewed through the Surgical Microscope with Preoperative Imaging to Compensate for Brain Shift.
复制标题
通过手术显微镜观察皮质血管与术前成像的对齐，以补偿大脑移位。
DOI：
10.1117/12.2547620
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Frisken,Sarah
中科院分区：
文献类型：
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作者：
Haouchine,Nazim;Juvekar,Parikshit;Golby,Alexandra;Wells3rd,WilliamM;Cotin,Stephane;Frisken,Sarah
脑移位是脑组织的非刚性变形，其受到脑脊液损失、组织操纵和重力等现象的影响。这种变形可能会对外科手术的结果产生负面影响，因为基于术前图像的外科手术计划变得不那么有效。我们提出了一种新的方法来补偿脑移位，该方法在术中神经外科手术期间将术前图像数据映射到变形的大脑，从而增加了实现大体全切除的可能性，同时降低了肿瘤周围健康组织的风险。通过3D/2D非刚性配准过程，将从术前成像导出的3D关节模型与术中通过手术显微镜观察到的血管的2D图像对齐。铰接的3D血管约束大脑的体积生物力学模型，以将皮质血管变形传播到实质并进而传播到肿瘤。使用满足投影和物理约束的能量最小化方法执行3D/2D非刚性配准。我们的方法进行评估，显示定量和定性的结果，并表现出其特别适用于实时手术指导的人脑的真实的和合成数据。
Brain shift is a non-rigid deformation of brain tissue that is affected by loss of cerebrospinal fluid, tissue manipulation and gravity among other phenomena. This deformation can negatively influence the outcome of a surgical procedure since surgical planning based on pre-operative image becomes less valid. We present a novel method to compensate for brain shift that maps preoperative image data to the deformed brain during intra-operative neurosurgical procedures and thus increases the likelihood of achieving a gross total resection while decreasing the risk to healthy tissue surrounding the tumor. Through a 3D/2D non-rigid registration process, a 3D articulated model derived from pre-operative imaging is aligned onto 2D images of the vessels viewed through the surgical miscroscopic intra-operatively. The articulated 3D vessels constrain a volumetric biomechanical model of the brain to propagate cortical vessel deformation to the parenchyma and in turn to the tumor. The 3D/2D non-rigid registration is performed using an energy minimization approach that satisfies both projective and physical constraints. Our method is evaluated on real and synthetic data of human brain showing both quantitative and qualitative results and exhibiting its particular suitability for real-time surgical guidance.