A population‐based model of the nonlinear dynamics of the thalamocortical feedback network displays intrinsic oscillations in the spindling (7–14 Hz) range
A population‐based model of the nonlinear dynamics of the thalamocortical feedback network displays intrinsic oscillations in the spindling (7–14 Hz) range
复制标题
基于群体的丘脑皮层反馈网络非线性动力学模型显示纺锤体 (7-14 Hz) 范围内的内在振荡
DOI：
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发表时间：
2005
影响因子：
3.4
通讯作者：
M. Denham
中科院分区：
文献类型：
--
作者：
N. Yousif;M. Denham
使用神经元群活动的威尔逊-考恩方程对丘脑皮质网络进行建模。我们表明，这种具有生物衍生参数的群体模型具有内在的非线性振荡动力学，并且振荡频率位于主轴范围内。纺锤体振荡是一种早期睡眠振荡，其特征是动作电位的高频爆发，随后是一段静止期，频率为 7-14Hz。纺锤体通常被认为是由丘脑内回路产生的，因为去皮的丘脑切片和孤立的丘脑网状核表现出纺锤体。然而，皮层反馈的作用已被证明可以调节和同步振荡。以前的建模研究主要使用基于电导的模型，因此该机制依赖于离子电流，特别是 T 型钙电流。在这里，我们证明纺锤频率振荡活动也可能由丘脑皮质回路的非线性动力学引起，并且我们使用分叉分析来检查这种振荡在模型中使用的参数的功能范围方面的鲁棒性。结果表明，丘脑皮质回路具有内在的非线性群体动力学，能够为纺锤体振荡频率范围内的振荡活动提供强有力的支持。
The thalamocortical network is modelled using the Wilson–Cowan equations for neuronal population activity. We show that this population model with biologically derived parameters possesses intrinsic nonlinear oscillatory dynamics, and that the frequency of oscillation lies within the spindle range. Spindle oscillations are an early sleep oscillation characterized by high‐frequency bursts of action potentials followed by a period of quiescence, at a frequency of 7–14 Hz. Spindles are generally regarded as being generated by intrathalamic circuitry, as decorticated thalamic slices and the isolated thalamic reticular nucleus exhibit spindles. However, the role of cortical feedback has been shown to regulate and synchronize the oscillation. Previous modelling studies have mainly used conductance‐based models and hence the mechanism relied upon the inclusion of ionic currents, particularly the T‐type calcium current. Here we demonstrate that spindle‐frequency oscillatory activity can also arise from the nonlinear dynamics of the thalamocortical circuit, and we use bifurcation analysis to examine the robustness of this oscillation in terms of the functional range of the parameters used in the model. The results suggest that the thalamocortical circuit has intrinsic nonlinear population dynamics which are capable of providing robust support for oscillatory activity within the frequency range of spindle oscillations.
DOI：
10.1073/pnas.93.23.13245
发表时间：
1996-11
影响因子：
11.1
作者：
Daniel Ulrich;J. Huguenard
通讯作者：
Daniel Ulrich;J. Huguenard
影响因子：
2.5
作者：
Anderson, JS;Carandini, M;Ferster, D
通讯作者：
Ferster, D