Glycosphingolipids and cell death: one aim, many ways.
Glycosphingolipids and cell death: one aim, many ways.
复制标题
DOI：
10.1007/s10495-015-1092-6
复制
发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Fernández-Checa JC
中科院分区：
文献类型：
--
作者：
Garcia-Ruiz C;Morales A;Fernández-Checa JC
Glycosphingolipids (GSLs) are a family of bioactive lipids that in addition to their role in the regulation of structural properties of membrane bilayers have emerged as crucial players in many biological processes and signal transduction pathways. Rather than being uniformly distributed within membrane bilayers, GSLs are localized in selective domains called lipid rafts where many signaling platforms operate. One of the most important functions of GSLs, particularly ceramide, is their ability to regulate cell death pathways and hence cell fate. This complex role is accomplished by the ability of GSLs to act in distinct subcellular strategic centers, such as mitochondria, endoplasmic reticulum (ER) or lysosomes to mediate apoptosis, ER stress, autophagy, lysosomal membrane permeabilization and necroptosis. Hence better understanding the role of GSLs in cell death may be of relevance for a number of pathological processes and diseases, including neurodegeneration, metabolic liver diseases and cancer.
