Is there a possible relation between atrophic gastritis and premature atherosclerosis?
Is there a possible relation between atrophic gastritis and premature atherosclerosis?
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DOI：
10.1111/j.1523-5378.2005.00356.x
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发表时间：
2005-12-01
期刊：
影响因子：
4.4
通讯作者：
Altekin, E
中科院分区：
文献类型：
--
作者：
Kutluana, U;Simsek, I;Altekin, E
背景在这项研究中，我们的目的是通过高同型半胱氨酸血症显示萎缩性胃炎和过早动脉粥样硬化之间的可能关系。34例萎缩性胃炎患者入组研究。对照组为非萎缩性胃炎患者35例。经典的心血管疾病危险因素在萎缩性胃炎和对照组之间没有显著差异。萎缩性胃炎的存在和程度进行了组织学评估和幽门螺杆菌感染的组织学和血清学方法确定。采用标准技术测量体重指数，采用生化方法测量空腹血糖、血清肌酐、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、维生素B12、叶酸和同型半胱氨酸水平。应用B型超声测量颈动脉内膜中层厚度，观察早期动脉粥样硬化。在萎缩性胃炎组中，血浆维生素B12水平显著较低（p = 0.00），同型半胱氨酸水平显著较高（p = 0.01）。两组间血浆叶酸水平无统计学显著差异（p = 0.728）。萎缩性胃炎组颈动脉内膜中层厚度高于对照组（0.516 mm vs 0.465 mm），但差异无统计学意义（p = 0.062）。结果表明，萎缩性胃炎可引起高同型半胱氨酸血症，这是一个独立的危险因素动脉粥样硬化和心血管疾病。然而，与对照组相比，萎缩性胃炎患者的颈动脉内膜中层厚度被发现较高，但没有达到统计学显著水平。
Background. In this study, we have aimed to show the possible relation between atrophic gastritis and premature atherosclerosis via hyperhomocysteinemia.Materials and Methods. Thirty-four patients with atrophic gastritis were enrolled to the study. The control group consisted of 35 patients with non-atrophic gastritis. Classical cardiovascular disease risk factors did not significantly differ between atrophic gastritis and control subjects. The presence and degree of atrophic gastritis were assessed histologically and Helicobacter pylori infection was determined by both histologic and serologic methods. Body mass index was measured by standard technique blood fasting glucose, serum creatinine, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, vitamin B12, folic acid, and homocysteine levels were measured by biochemical methods. Carotid intima-media thickness was measured by B-mode ultrasonography to examine the premature atherosclerosis.Results. Plasma vitamin B12 levels were significantly lower (p = .00) and homocysteine levels were significantly higher (p = .01) in the atrophic gastritis group. There was no statistically significant difference in plasma folic acid levels between the two groups (p = .728). Carotid intima-media thickness was higher in the atrophic gastritis group than in the control group (0.516 mm versus 0.465 mm), but this difference did not show any statistical significance (p = .062).Conclusion. Our results showed that atrophic gastritis may cause hyperhomocysteinemia, which is an independent risk factor for atherosclerosis and cardiovascular diseases. However, when compared with controls, carotid intima-media thickness of the atrophic gastritis patients was found to be higher but did not reach statistically significant levels.