Hormonal Regulation of Response to Oxidative Stress in Insects-An Update.
Hormonal Regulation of Response to Oxidative Stress in Insects-An Update.
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DOI：
10.3390/ijms161025788
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发表时间：
2015-10-27
影响因子：
5.6
通讯作者：
Krishnan N
中科院分区：
文献类型：
--
作者：
Kodrík D;Bednářová A;Zemanová M;Krishnan N
昆虫和其他生物一样，在其一生中必须处理各种各样潜在的具有挑战性的环境因素。这种挑战的一个重要例子是氧化应激现象。本文综述了脂肪动力学激素（adipokinetic hormone， AKH）作为主要应激反应激素在昆虫抗氧化应激途径激活中的作用。重点分析了由各种应激源诱导的氧化应激实验，并通过合适的生物标志物进行监测，并详细描述了AKH在抗应激反应中的作用。这些反应的特征是昆虫体内的AKH水平显著增加，并且在应激源与AKH共同作用后，被应激源干扰的标记物有效逆转。本文还讨论了AKH在抗氧化应激反应中的作用机制：这可能涉及在细胞外和细胞内Ca2+储存存在的情况下同时使用蛋白激酶C和环腺苷3 ',5 ' -单磷酸途径，并可能涉及FoxO转录因子。本文还讨论了其他昆虫激素在抗氧化防御反应中的作用。
Insects, like other organisms, must deal with a wide variety of potentially challenging environmental factors during the course of their life. An important example of such a challenge is the phenomenon of oxidative stress. This review summarizes the current knowledge on the role of adipokinetic hormones (AKH) as principal stress responsive hormones in insects involved in activation of anti-oxidative stress response pathways. Emphasis is placed on an analysis of oxidative stress experimentally induced by various stressors and monitored by suitable biomarkers, and on detailed characterization of AKH’s role in the anti-stress reactions. These reactions are characterized by a significant increase of AKH levels in the insect body, and by effective reversal of the markers—disturbed by the stressors—after co-application of the stressor with AKH. A plausible mechanism of AKH action in the anti-oxidative stress response is discussed as well: this probably involves simultaneous employment of both protein kinase C and cyclic adenosine 3′,5′-monophosphate pathways in the presence of extra and intra-cellular Ca2+ stores, with the possible involvement of the FoxO transcription factors. The role of other insect hormones in the anti-oxidative defense reactions is also discussed.