Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation.
Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation.
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Cek5 是 Eph 亚类的一种酪氨酸激酶，在神经视网膜分化过程中被激活。
DOI：
10.1006/dbio.1994.1165
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发表时间：
1994
影响因子：
2.7
通讯作者：
Risau,W
中科院分区：
文献类型：
--
作者：
Pasquale,EB;Connor,RJ;Rocholl,D;Schnurch,H;Risau,W
Cek5，受体型酪氨酸激酶的Eph亚类，其变体形式Cek5+的表达进行了检查在鸡神经视网膜发育过程中。Cek5在所检查的视网膜发育的所有阶段都以高水平存在，而Cek5+在分化期间最丰富。Cek5 mRNA表达和免疫反应性在未分化视网膜中均匀分布。随着分化，Cek 5变得集中在内部和外部丛状层中。虽然在整个视网膜发育过程中只观察到Cek5蛋白表达的中度变化，但在分化过程中，Cek5在体内酪氨酸上的磷酸化显著增加。这表明Cek5配体以高水平表达并引起Cek5活化。因此，Cek5可能在视网膜形态发生中发挥积极作用，特别是在建立神经元间接触期间。
The expression of Cek5, a receptor-type tyrosine kinase of the Eph subclass, and its variant form Cek5+were examined in the chick neural retina during development. Cek5 is present at high levels at all stages of retinal development examined, while Cek5+is most abundant during differentiation. Cek5 mRNA expression and immunoreactivity are evenly distributed in the undifferentiated retina. With differentiation, Cek5 becomes concentrated in the inner and outer plexiform layers. While only moderate changes in Cek5 protein expression are observed throughout retinal development, Cek5 phosphorylation on tyrosinein vivois dramatically increased during differentiation. This suggests that the Cek5 ligand is expressed at high levels and causes Cek5 activation. Thus, Cek5 is likely to play an active role in retinal morphogenesis, particularly during the establishment of interneuronal contacts.