Diagnostic accuracy of 14-3-3 η protein in rheumatoid arthritis: A meta-analysis.
Diagnostic accuracy of 14-3-3 η protein in rheumatoid arthritis: A meta-analysis.
复制标题
14-3-3 δ 蛋白在类风湿性关节炎中的诊断准确性：荟萃分析。
DOI：
10.1111/1756-185x.13921
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发表时间：
2020-11
影响因子：
2.5
通讯作者：
Mo B
中科院分区：
文献类型：
--
作者：
Wang D;Cui Y;Lei H;Cao D;Tang G;Huang H;Yuan T;Rao L;Mo B
目的：评价14-3-3η蛋白对类风湿关节炎(RA)的诊断价值。检索PubMed、EMBASE和Web of Science以获取符合条件的研究。纳入2020年2月20日之前发表的英文文章。诊断准确性研究的质量评估2用于评估纳入文章的偏倚和应用方面的风险。采用随机效应模型对14-3-3η蛋白对类风湿关节炎的诊断指标进行合并分析。亚群分析用于探索异质性的来源。采用Deek‘s漏斗图不对称性检验评价发表偏倚的存在。共纳入13项研究(1554名阳性参与者和1934名阴性参与者)。合并敏感度和特异度分别为0.73(95%CI 0.71~0.75)和0.88(95%CI 0.87~0.90)。合并的阳性/阴性似然比分别为5.98(95%CI 4.39~8.14)和0.28(95%CI 0.21~0.37)。合并诊断优势比为23.48(95%可信区间为13.76~40.08)，曲线下面积为0.9245。亚组分析结果表明，种族和对照组可能是异质性的来源。敏感性分析结果稳定。未发现显著的发表偏倚。目前的证据表明，14-3-3η蛋白对RA的诊断具有一定的准确性。
To evaluate the overall diagnostic performance of 14‐3‐3 η protein in patients with rheumatoid arthritis (RA). PubMed, EMBASE, and Web of Science were searched to acquire eligible studies. Articles published in English before 20 February 2020 were included. Quality Assessment of Diagnostic Accuracy Studies 2 was used to evaluate the risk of bias and application concern of the included articles. Pooled analysis of diagnostic indicators of 14‐3‐3 η protein for RA was conducted by using a random effects model. Subgroup analysis was used to explore the sources of heterogeneity. Deeks' funnel plot asymmetry test was used to evaluate for the presence of publication bias. A total of 13 studies (1554 positive and 1934 negative participants) were included. The pooled sensitivity and specificity were 0.73 (95% CI 0.71‐0.75) and 0.88 (95% CI 0.87‐0.90), respectively. The pooled positive/negative likelihood were 5.98 (95% CI 4.39‐8.14) and 0.28 (95% CI 0.21‐0.37), respectively. In addition, the pooled diagnostic odds ratio was 23.48 (95% CI 13.76‐40.08) and the area under curve was 0.9245. The results of subgroup analysis indicated that ethnicity and control group might be the source of heterogeneity. The results of sensitivity analysis were stable. No significant publication bias was found. The current evidence indicated that 14‐3‐3 η protein has moderate accuracy for the diagnosis of RA.