Application of comparative biology in GO functional annotation: the mouse model
Application of comparative biology in GO functional annotation: the mouse model
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DOI：
10.1007/s00335-015-9580-0
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发表时间：
2015-10-01
期刊：
影响因子：
2.5
通讯作者：
Blake, Judith A.
中科院分区：
文献类型：
--
作者：
Drabkin, Harold J.;Christie, Karen R.;Blake, Judith A.
基因本体论(GO)是现代生物知识表示的重要组成部分，在基因组和遗传数据的计算分析中具有重要作用。基因本体论联盟(GOC)由一个庞大的贡献者团队组成，其中包括来自大多数模式生物数据库组的管理团队，以及专注于表示与特定人类疾病相关的数据的管理团队。生成一致和全面的注释的关键是开发和使用共享的标准和管理质量的衡量标准。GOC邀请所有贡献者致力于确定的管理标准，该标准是在实验室小鼠基因注释的背景下提出的。全面了解围棋注释的起源、认识论和覆盖范围对于最有效地使用围棋资源至关重要。这里描述了在鼠标系统中捕获功能数据的比较方法的应用。
The Gene Ontology (GO) is an important component of modern biological knowledge representation with great utility for computational analysis of genomic and genetic data. The Gene Ontology Consortium (GOC) consists of a large team of contributors including curation teams from most model organism database groups as well as curation teams focused on representation of data relevant to specific human diseases. Key to the generation of consistent and comprehensive annotations is the development and use of shared standards and measures of curation quality. The GOC engages all contributors to work to a defined standard of curation that is presented here in the context of annotation of genes in the laboratory mouse. Comprehensive understanding of the origin, epistemology, and coverage of GO annotations is essential for most effective use of GO resources. Here the application of comparative approaches to capturing functional data in the mouse system is described.